Seroatlas · Human Serome Atlas

VCX

Variable charge X-linked protein 1

Also known as: VCX-10r, VCX-B1, VCX1, VCX1_HUMAN, VCX10R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H320
Gene
VCX
Ensembl
ENSG00000182583
Chromosome
X
Canonical length
206 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q9H320|VCX
     1  MSPKPRASGP PAKATEAGKR KSSSQPSPSD PKKKTTKVAK KGKAVRRGRR GKKGAATKMA
    61  AVTAPEAESA PAAPGPSDQP SQELPQHELP PEEPVSEGTQ HDPLSQEAEL EEPLSQESEV
   121  EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEV EEPLSQESQV EEPLSQESEM
   181  EEPLSQESQV EEPPSQESEM EELPSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VCX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.73
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • testis: 30 nTPM
  • basal ganglia: 0.3 nTPM
  • cerebral cortex: 0.3 nTPM
  • retina: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • duodenum: 0.2 nTPM

Single-cell type

  • early primary spermatocytes: 1,124 nCPM
  • differentiating spermatogonia: 767 nCPM
  • undifferentiated spermatogonia: 152 nCPM
  • late primary spermatocytes: 105 nCPM
  • late spermatids: 49 nCPM
  • early spermatids: 31 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • pons: 0.3 nTPM
  • white matter: 0.3 nTPM
  • amygdala: 0.2 nTPM
  • basal ganglia: 0.2 nTPM
  • hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0.34
gnomAD missense Z
-2.81

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VCX as an antibody target. Whether an autoantibody or antibody against VCX could matter depends on whether native VCX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VCX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VCX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VCX. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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