Seroatlas · Human Serome Atlas

VCF2

Protein VCF2

Also known as: CXorf44, FAM104B, FLJ20434, VCF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5XKR9
Gene
VCF2
Ensembl
ENSG00000182518
Chromosome
X
Canonical length
115 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for VCF2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>Q5XKR9|VCF2
     1  MGGCPVRKRR RNGSKEGNHH STQPKRNKRN PIFQDSQDTE FSWSDNERSS SRINIPERAS
    61  GPEGNLNQIV TEPDANFPQF LHEGLSKPVY VINWFMSFGP EIKLNTSQQG RNQAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VCF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
42 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 42 nTPM
  • fallopian tube: 33 nTPM
  • kidney: 27 nTPM
  • thyroid gland: 26 nTPM
  • retina: 21 nTPM
  • spinal cord: 20 nTPM

Single-cell type

  • late spermatids: 351 nCPM
  • fallopian tube ciliated cells: 139 nCPM
  • early spermatids: 132 nCPM
  • respiratory ciliated cells: 129 nCPM
  • esophageal suprabasal cells: 84 nCPM
  • extravillous trophoblasts: 70 nCPM

Immune cell

  • intermediate monocyte: 23 nTPM
  • myeloid DC: 22 nTPM
  • plasmacytoid DC: 22 nTPM
  • non-classical monocyte: 20 nTPM
  • T-reg: 19 nTPM
  • naive CD4 T-cell: 19 nTPM

Brain region

  • white matter: 27 nTPM
  • basal ganglia: 24 nTPM
  • cerebral cortex: 23 nTPM
  • hypothalamus: 23 nTPM
  • medulla oblongata: 22 nTPM
  • pons: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.92
gnomAD pLI
0.02
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VCF2 as an antibody target. Whether an autoantibody or antibody against VCF2 could matter depends on whether native VCF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VCF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VCF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VCF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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