Seroatlas · Human Serome Atlas

UTS2R

Urotensin-2 receptor

Also known as: GPR14, UR2R_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UKP6
Gene: UTS2R
Ensembl: ENSG00000181408
Chromosome: 17
Canonical length: 389 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable urotensin II receptor activity. Predicted to be involved in neuropeptide signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q9UKP6|UTS2R
     1  MALTPESPSS FPGLAATGSS VPEPPGGPNA TLNSSWASPT EPSSLEDLVA TGTIGTLLSA
    61  MGVVGVVGNA YTLVVTCRSL RAVASMYVYV VNLALADLLY LLSIPFIVAT YVTKEWHFGD
   121  VGCRVLFGLD FLTMHASIFT LTVMSSERYA AVLRPLDTVQ RPKGYRKLLA LGTWLLALLL
   181  TLPVMLAMRL VRRGPKSLCL PAWGPRAHRA YLTLLFATSI AGPGLLIGLL YARLARAYRR
   241  SQRASFKRAR RPGARALRLV LGIVLLFWAC FLPFWLWQLL AQYHQAPLAP RTARIVNYLT
   301  TCLTYGNSCA NPFLYTLLTR NYRDHLRGRV RGPGSGGGRG PVPSLQPRAR FQRCSGRSLS
   361  SCSPQPTDSL VLAPAAPARP APEGPRAPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTS2R can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 3.4 nTPM

Expression across tissuesHPA

Tissue

testis: 3.4 nTPM
thyroid gland: 3.2 nTPM
skeletal muscle: 1.6 nTPM
cerebral cortex: 1.5 nTPM
skin: 1.5 nTPM
heart muscle: 1.4 nTPM

Single-cell type

early primary spermatocytes: 33 nCPM
late spermatids: 8.4 nCPM
early spermatids: 8 nCPM
myosatellite cells: 5.1 nCPM
epididymal efferent duct ciliated cells: 2.9 nCPM
thymic myoid cells: 2.7 nCPM

Immune cell

neutrophil: 2 nTPM
basophil: 0.5 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

cerebral cortex: 18 nTPM
cerebellum: 16 nTPM
amygdala: 15 nTPM
hypothalamus: 14 nTPM
thalamus: 13 nTPM
medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM
7 transmembrane receptor (rhodopsin family)
Urotensin II receptor

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTS2R as an antibody target. Whether an autoantibody or antibody against UTS2R could matter depends on whether native UTS2R is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTS2R is annotated at the cell surface, where native UTS2R is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UTS2R as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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