Seroatlas · Human Serome Atlas

UTS2B

Urotensin-2B

Also known as: U2B, URP, UTS2B_HUMAN, UTS2D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q765I0
Gene
UTS2B
Ensembl
ENSG00000188958
Chromosome
3
Canonical length
119 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted - unknown location

OverviewNCBI Gene

Predicted to enable G protein-coupled receptor binding activity. Predicted to be involved in regulation of blood pressure. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>Q765I0|UTS2B
     1  MNKILSSTVC FGLLTLLSVL SFLQSVHGRP YLTQGNEIFP DKKYTNREEL LLALLNKNFD
    61  FQRPFNTDLA LPNKLEELNQ LEKLKEQLVE EKDSETSYAV DGLFSSHPSK RACFWKYCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTS2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
5.9 nTPM

Expression across tissuesHPA

Tissue

  • retina: 5.9 nTPM
  • duodenum: 3.2 nTPM
  • testis: 1.9 nTPM
  • liver: 1.6 nTPM
  • small intestine: 1.5 nTPM
  • breast: 1.1 nTPM

Single-cell type

  • cardiomyocytes: 90 nCPM
  • epicardial cells: 50 nCPM
  • adipocytes: 26 nCPM
  • late primary spermatocytes: 24 nCPM
  • undifferentiated spermatogonia: 23 nCPM
  • late spermatids: 15 nCPM

Immune cell

  • memory B-cell: 2.9 nTPM
  • naive B-cell: 1.8 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 7.1 nTPM
  • white matter: 5.7 nTPM
  • cerebral cortex: 5.6 nTPM
  • amygdala: 5.4 nTPM
  • hypothalamus: 5.3 nTPM
  • basal ganglia: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTS2B as an antibody target. Whether an autoantibody or antibody against UTS2B could matter depends on whether native UTS2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTS2B is annotated as secreted, so native UTS2B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UTS2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UTS2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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