Seroatlas · Human Serome Atlas

UTS2

Urotensin-2

Also known as: PRO1068, U-II, UCN2, UII, UTS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95399
Gene: UTS2
Ensembl: ENSG00000049247
Chromosome: 1
Canonical length: 124 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>O95399|UTS2
     1  MYKLASCCLL FIGFLNPLLS LPLLDSREIS FQLSAPHEDA RLTPEELERA SLLQILPEML
    61  GAERGDILRK ADSSTNIFNP RGNLRKFQDF SGQDPNILLS HLLARIWKPY KKRETPDCFW
   121  KYCV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 6.4 nTPM
adrenal gland: 3.7 nTPM
hypothalamus: 3.2 nTPM
bone marrow: 2.7 nTPM
lymph node: 1.7 nTPM
prostate: 1.2 nTPM

Single-cell type

mast cells: 39 nCPM
cardiomyocytes: 30 nCPM
epicardial cells: 21 nCPM
nk-cells: 18 nCPM
paneth cells: 16 nCPM
megakaryocytes: 12 nCPM

Immune cell

T-reg: 45 nTPM
basophil: 8.6 nTPM
MAIT T-cell: 6.7 nTPM
NK-cell: 6.1 nTPM
gdT-cell: 5 nTPM
memory CD8 T-cell: 4.5 nTPM

Brain region

medulla oblongata: 99 nTPM
pons: 60 nTPM
white matter: 51 nTPM
midbrain: 13 nTPM
hypothalamus: 11 nTPM
spinal cord: 9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0.03
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Urotensin II, conserved site
Urotensin II

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTS2 as an antibody target. Whether an autoantibody or antibody against UTS2 could matter depends on whether native UTS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTS2 is annotated as secreted, so native UTS2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UTS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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