Seroatlas · Human Serome Atlas

UTP6

U3 small nucleolar RNA-associated protein 6 homolog

Also known as: C17orf40, HCA66, UTP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYH9
Gene: UTP6
Ensembl: ENSG00000108651
Chromosome: 17
Canonical length: 597 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitotic chromosome

OverviewNCBI Gene

Predicted to enable snoRNA binding activity. Involved in ribosomal small subunit biogenesis. Located in chromosome and nucleolus. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>Q9NYH9|UTP6
     1  MAEIIQERIE DRLPELEQLE RIGLFSHAEI KAIIKKASDL EYKIQRRTLF KEDFINYVQY
    61  EINLLELIQR RRTRIGYSFK KDEIENSIVH RVQGVFQRAS AKWKDDVQLW LSYVAFCKKW
   121  ATKTRLSKVF SAMLAIHSNK PALWIMAAKW EMEDRLSSES ARQLFLRALR FHPECPKLYK
   181  EYFRMELMHA EKLRKEKEEF EKASMDVENP DYSEEILKGE LAWIIYKNSV SIIKGAEFHV
   241  SLLSIAQLFD FAKDLQKEIY DDLQALHTDD PLTWDYVARR ELEIESQTEE QPTTKQAKAV
   301  EVGRKEERCC AVYEEAVKTL PTEAMWKCYI TFCLERFTKK SNSGFLRGKR LERTMTVFRK
   361  AHELKLLSEC QYKQLSVSLL CYNFLREALE VAVAGTELFR DSGTMWQLKL QVLIESKSPD
   421  IAMLFEEAFV HLKPQVCLPL WISWAEWSEG AKSQEDTEAV FKKALLAVIG ADSVTLKNKY
   481  LDWAYRSGGY KKARAVFKSL QESRPFSVDF FRKMIQFEKE QESCNMANIR EYYERALREF
   541  GSADSDLWMD YMKEELNHPL GRPENCGQIY WRAMKMLQGE SAEAFVAKHA MHQTGHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 30 nTPM
spleen: 25 nTPM
liver: 24 nTPM
cervix: 22 nTPM
prostate: 22 nTPM
hippocampal formation: 21 nTPM

Single-cell type

early primary spermatocytes: 119 nCPM
endometrial glandular cells: 81 nCPM
microglia: 73 nCPM
differentiating spermatogonia: 69 nCPM
extravillous trophoblasts: 69 nCPM
ocular epithelial cells: 65 nCPM

Immune cell

plasmacytoid DC: 21 nTPM
basophil: 16 nTPM
naive B-cell: 15 nTPM
myeloid DC: 15 nTPM
neutrophil: 14 nTPM
memory B-cell: 13 nTPM

Brain region

choroid plexus: 9.7 nTPM
cerebellum: 8.4 nTPM
hypothalamus: 7.6 nTPM
white matter: 7.6 nTPM
cerebral cortex: 7.3 nTPM
midbrain: 7.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.98
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

snoRNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

HAT (Half-A-TPR) repeat
Tetratricopeptide-like helical domain superfamily
U3 small nucleolar RNA-associated protein 6
U3 small nucleolar RNA-associated protein 6, N-terminal
U3 small nucleolar RNA-associated protein 6 homolog, C-terminal
U3 small nucleolar RNA-associated protein 6
U3 small nucleolar RNA-associated protein 6 C-terminal

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP6 as an antibody target. Whether an autoantibody or antibody against UTP6 could matter depends on whether native UTP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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