Seroatlas · Human Serome Atlas

UTP23

rRNA-processing protein UTP23 homolog

Also known as: C8orf53, MGC14595, UTP23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BRU9
Gene: UTP23
Ensembl: ENSG00000147679
Chromosome: 8
Canonical length: 249 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Predicted to be involved in rRNA processing. Predicted to act upstream of or within endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Implicated in colorectal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

249 residues, UniProt reviewed canonical sequence.

>Q9BRU9|UTP23
     1  MKITRQKHAK KHLGFFRNNF GVREPYQILL DGTFCQAALR GRIQLREQLP RYLMGETQLC
    61  TTRCVLKELE TLGKDLYGAK LIAQKCQVRN CPHFKNAVSG SECLLSMVEE GNPHHYFVAT
   121  QDQNLSVKVK KKPGVPLMFI IQNTMVLDKP SPKTIAFVKA VESGQLVSVH EKESIKHLKE
   181  EQGLVKNTEQ SRRKKRKKIS GPNPLSCLKK KKKAPDTQSS ASEKKRKRKR IRNRSNPKVL
   241  SEKQNAEGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 12 nTPM
ovary: 11 nTPM
lymph node: 10 nTPM
thyroid gland: 10 nTPM
adipose tissue: 9.7 nTPM
breast: 9 nTPM

Single-cell type

brain inhibitory neurons: 90 nCPM
brain excitatory neurons: 75 nCPM
cardiomyocytes: 67 nCPM
myonuclei: 61 nCPM
retinal horizontal cells: 58 nCPM
pancreatic acinar cells: 57 nCPM

Immune cell

basophil: 50 nTPM
naive CD4 T-cell: 48 nTPM
T-reg: 44 nTPM
memory B-cell: 44 nTPM
naive B-cell: 42 nTPM
gdT-cell: 40 nTPM

Brain region

white matter: 14 nTPM
cerebellum: 14 nTPM
spinal cord: 13 nTPM
basal ganglia: 12 nTPM
hypothalamus: 12 nTPM
cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0.09
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.91
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

LSU-rRNA)
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA
5.8S rRNA

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Fcf1/UTP23
PIN-like domain superfamily
Fcf1
UTP23, sensor motif region
UTP23 sensor motif

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP23 as an antibody target. Whether an autoantibody or antibody against UTP23 could matter depends on whether native UTP23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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