Seroatlas · Human Serome Atlas

UTP14C

U3 small nucleolar RNA-associated protein 14 homolog C

Also known as: 2700066J21Rik, KIAA0266, UT14C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5TAP6
Gene
UTP14C
Ensembl
ENSG00000253797
Chromosome
13
Canonical length
766 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be involved in several processes, including meiotic cell cycle; rRNA processing; and spermatogenesis. Located in cytosol and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

766 residues, UniProt reviewed canonical sequence.

>Q5TAP6|UTP14C
     1  MNVNQVAENL ALSHQEELVD LPKNYPLSEN EDEGDSDGER KHQKLLEAII SLDGKNRRKL
    61  AERSEASLKV SEFSVSSEGS GEKLGLADLL EPVKTSSSLA TVKKQLNRVK SKKVVELPLN
   121  KEKIEQIHRE VAFSKTSQVL SKWDPIILKN QQAEQLVFPL GKEQPAIAPI EHALSGWKAR
   181  TPLEQEIFNL LHKNKQPVTD PLLTPMEKAS LQAMSLEEAK MHRAELQRAR ALQSYYEAKA
   241  RKEKKIKSKK YHKVVKKGKA KKALKEFEQL QKVNPTVALE EMEKIENARM MERMSLKHQN
   301  SGKWAKSKAI MAKYDLEARQ AMQEQLAKNK ELTQKLQVAS ESEEEEGGTE VEELLVPHVA
   361  NEVQMNVDGP NPWMFRSCTS DTKEAATQED PEQVPELAAH EVSASEAEER PVAEEEILLR
   421  EFEERQSLRK RSELNQDAEP ASSQETKDSS SQEVLSELRA LSQKLKEKHQ SRKQKASSEG
   481  TVPQVQREEP APEEAEPLLL QRSERVQTLE ELEELGKEDC FQNKELPRPV LEGQQSERTP
   541  NNRPDAPKEK KEKEQLINLQ NFLTTQSPSV RSLAVPTIIE ELEDEEERDQ RQMIKEAFAG
   601  DDVIRDFLKE KREAVEASKP KDVDLTLPGW GEWGGVGLKP SAKKRRQFLI KAPEGPPRKD
   661  KNLPNVIISE KRNIHAAAHQ VQVLPYPFTH HRQFERTIQT PIGSTWNTQR AFQKLTTPKV
   721  VTKPGHIIKP IKAEDVGYQS SSRSDLPVIQ RNPKRITTRH NKEEKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP14C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
4.2 nTPM

Expression across tissuesHPA

Tissue

  • liver: 4.2 nTPM
  • choroid plexus: 3.7 nTPM
  • basal ganglia: 3.6 nTPM
  • cerebellum: 3.5 nTPM
  • midbrain: 3.5 nTPM
  • pancreas: 3.3 nTPM

Single-cell type

  • podocytes: 14 nCPM
  • loop of henle epithelial cells: 12 nCPM
  • proximal tubule cells: 11 nCPM
  • distal convoluted tubule cells: 10 nCPM
  • renal collecting duct intercalated cells: 10 nCPM
  • renal connecting tubule cells: 8.3 nCPM

Immune cell

  • eosinophil: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 2 nTPM
  • white matter: 1.4 nTPM
  • amygdala: 1.3 nTPM
  • midbrain: 1.3 nTPM
  • hypothalamus: 1.1 nTPM
  • thalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0.01
gnomAD missense Z
-0.47
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP14C as an antibody target. Whether an autoantibody or antibody against UTP14C could matter depends on whether native UTP14C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP14C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP14C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UTP14C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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