Seroatlas · Human Serome Atlas

UTP11

Probable U3 small nucleolar RNA-associated protein 11

Also known as: CGI-94, UTP11_HUMAN, UTP11L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3A2
Gene: UTP11
Ensembl: ENSG00000183520
Chromosome: 1
Canonical length: 253 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Involved in nervous system development; positive regulation of apoptotic process; and ribosomal small subunit biogenesis. Located in cytosol; extracellular space; and nuclear lumen. Part of small-subunit processome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>Q9Y3A2|UTP11
     1  MAAAFRKAAK SRQREHRERS QPGFRKHLGL LEKKKDYKLR ADDYRKKQEY LKALRKKALE
    61  KNPDEFYYKM TRVKLQDGVH IIKETKEEVT PEQLKLMRTQ DVKYIEMKRV AEAKKIERLK
   121  SELHLLDFQG KQQNKHVFFF DTKKEVEQFD VATHLQTAPE LVDRVFNRPR IETLQKEKVK
   181  GVTNQTGLKR IAKERQKQYN CLTQRIEREK KLFVIAQKIQ TRKDLMDKTQ KVKVKKETVN
   241  SPAIYKFQSR RKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 112 nTPM
tongue: 80 nTPM
heart muscle: 20 nTPM
colon: 18 nTPM
smooth muscle: 18 nTPM
urinary bladder: 18 nTPM

Single-cell type

thymic myoid cells: 235 nCPM
oocytes: 157 nCPM
late primary spermatocytes: 124 nCPM
esophageal basal cells: 97 nCPM
syncytiotrophoblasts: 93 nCPM
esophageal suprabasal cells: 89 nCPM

Immune cell

non-classical monocyte: 36 nTPM
NK-cell: 32 nTPM
intermediate monocyte: 30 nTPM
classical monocyte: 27 nTPM
myeloid DC: 27 nTPM
plasmacytoid DC: 26 nTPM

Brain region

white matter: 20 nTPM
medulla oblongata: 18 nTPM
midbrain: 18 nTPM
cerebral cortex: 18 nTPM
pons: 17 nTPM
spinal cord: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UTP11.

Disease | ImmuneIEDB

Conditions an epitope on UTP11 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.86
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small-subunit processome, Utp11
Utp11 protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UTP11 as an antibody target. Whether an autoantibody or antibody against UTP11 could matter depends on whether native UTP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UTP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UTP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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