UTF1

Protein identityUniProt · HPA

UniProt accession

Q5T230

Gene

UTF1

Ensembl

ENSG00000171794

Chromosome

10

Canonical length

341 aa

Protein class

Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

The protein encoded by this gene is a leucine zipper-containing transcriptional coactivator that may link the upstream activator ATF2 with the basal transcription complex. The encoded protein is closely associated with chromatin and is required for the proper differentiation of embryonic carcinoma and embryonic stem cells. Found nearly exclusively in pluripotent cells, this protein can also serve as a transcriptional repressor. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q5T230|UTF1
     1  MLLRPRRPPP LAPPAPPSPA SPDPEPRTPG DAPGTPPRRP ASPSALGELG LPVSPGSAQR
    61  TPWSARETEL LLGTLLQPAV WRALLLDRRQ ALPTYRRVSA ALAQQQVRRT PAQCRRRYKF
   121  LKDKFREAHG QPPGPFDEQI RKLMGLLGDN GRKRPRRRSP GSGRPQRARR PVPNAHAPAP
   181  SEPDATPLPT ARDRDADPTW TLRFSPSPPK SADASPAPGS PPAPAPTALA TCIPEDRAPV
   241  RGPGSPPPPP AREDPDSPPG RPEDCAPPPA APPSLNTALL QTLGHLGDIA NILGPLRDQL
   301  LTLNQHVEQL RGAFDQTVSL AVGFILGSAA AERGVLRDPC Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UTF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.61

Highest tissue expression

5.4 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0.51

gnomAD missense Z

0.85

DepMap mean gene effect

0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• male gonad development
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• transcription coactivator activity

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Myb/SANT-like DNA-binding domain 4
• Myb/SANT-like DNA-binding domain

KeywordsUniProt

• Activator
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of UTF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TBP