Seroatlas · Human Serome Atlas

USP42

Ubiquitin carboxyl-terminal hydrolase 42

Also known as: FLJ12697, UBP42_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9J4
Gene: USP42
Ensembl: ENSG00000106346
Chromosome: 7
Canonical length: 1324 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination; regulation of apoptotic process; and regulation of protein stability. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1324 residues, UniProt reviewed canonical sequence.

>Q9H9J4|USP42
     1  MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA
    61  VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC
   121  FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI
   181  NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS
   241  RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
   301  SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIVYVLYAVL
   361  VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE
   421  LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS
   481  MSSPNGNSSV NRASPVNASA SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN
   541  LHSNSLENPT KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
   601  SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE LQEPMTLNGA
   661  NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP GKLMPAPLLS LPEDKILETF
   721  RLSNKLKGST DEMSAPGAER GPPEDRDAEP QPGSPAAESL EEPDAAAGLS STKKAPPPRD
   781  PGTPATKEGA WEAMAVAPEE PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA
   841  EGPRDSALAE APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
   901  APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR GHYRSRRERS
   961  SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP GHGDRLSPGE RRSLGRCSHH
  1021  HSRHRSGVEL DWVRHHYTEG ERGWGREKFY PDRPRWDRCR YYHDRYALYA ARDWKPFHGG
  1081  REHERAGLHE RPHKDHNRGR RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV
  1141  AGDNCNLSDR FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
  1201  KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF VKDSELHLPR
  1261  VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM ESRDDRCRLF EYGQGKRRYL
  1321  ELGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
bone marrow: 13 nTPM
cerebellum: 7.1 nTPM
retina: 5.5 nTPM
thymus: 5.4 nTPM
skin: 5.2 nTPM

Single-cell type

early spermatids: 102 nCPM
early primary spermatocytes: 87 nCPM
undifferentiated spermatogonia: 86 nCPM
late primary spermatocytes: 79 nCPM
neutrophils: 73 nCPM
endometrial ciliated cells: 73 nCPM

Immune cell

naive CD8 T-cell: 1.1 nTPM
eosinophil: 0.9 nTPM
MAIT T-cell: 0.7 nTPM
basophil: 0.6 nTPM
intermediate monocyte: 0.6 nTPM
memory CD4 T-cell: 0.6 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 8.5 nTPM
hypothalamus: 8.1 nTPM
midbrain: 8 nTPM
white matter: 8 nTPM
basal ganglia: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: -1.63
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP42 as an antibody target. Whether an autoantibody or antibody against USP42 could matter depends on whether native USP42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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