Seroatlas · Human Serome Atlas

USP30

Ubiquitin carboxyl-terminal hydrolase 30

Also known as: FLJ40511, MGC10702, UBP30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q70CQ3
Gene: USP30
Ensembl: ENSG00000135093
Chromosome: 12
Canonical length: 517 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>Q70CQ3|USP30
     1  MLSSRAEAAM TAADRAIQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK
    61  KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT SQYSRDQKEP PSHQYLSLTL
   121  LHLLKALSCQ EVTDDEVLDA SCLLDVLRMY RWQISSFEEQ DAHELFHVIT SSLEDERDRQ
   181  PRVTHLFDVH SLEQQSEITP KQITCRTRGS PHPTSNHWKS QHPFHGRLTS NMVCKHCEHQ
   241  SPVRFDTFDS LSLSIPAATW GHPLTLDHCL HHFISSESVR DVVCDNCTKI EAKGTLNGEK
   301  VEHQRTTFVK QLKLGKLPQC LCIHLQRLSW SSHGTPLKRH EHVQFNEFLM MDIYKYHLLG
   361  HKPSQHNPKL NKNPGPTLEL QDGPGAPTPV LNQPGAPKTQ IFMNGACSPS LLPTLSAPMP
   421  FPLPVVPDYS SSTYLFRLMA VVVHHGDMHS GHFVTYRRSP PSARNPLSTS NQWLWVSDDT
   481  VRKASLQEVL SSSAYLLFYE RVLSRMQHQS QECKSEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

liver: 15 nTPM
parathyroid gland: 14 nTPM
testis: 13 nTPM
duodenum: 11 nTPM
small intestine: 10 nTPM
bone marrow: 10 nTPM

Single-cell type

late spermatids: 91 nCPM
retinal pigment epithelial cells: 55 nCPM
rod photoreceptor cells: 55 nCPM
oligodendrocytes: 55 nCPM
pituicytes/fscs: 44 nCPM
adipocytes: 40 nCPM

Immune cell

NK-cell: 23 nTPM
MAIT T-cell: 20 nTPM
gdT-cell: 18 nTPM
memory B-cell: 17 nTPM
naive B-cell: 17 nTPM
memory CD8 T-cell: 17 nTPM

Brain region

white matter: 48 nTPM
hypothalamus: 34 nTPM
cerebral cortex: 34 nTPM
basal ganglia: 32 nTPM
medulla oblongata: 32 nTPM
thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP30 as an antibody target. Whether an autoantibody or antibody against USP30 could matter depends on whether native USP30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...