Seroatlas · Human Serome Atlas

USP29

Ubiquitin carboxyl-terminal hydrolase 29

Also known as: UBP29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HBJ7
Gene: USP29
Ensembl: ENSG00000131864
Chromosome: 19
Canonical length: 922 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of type I interferon-mediated signaling pathway; and protein K48-linked deubiquitination. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

922 residues, UniProt reviewed canonical sequence.

>Q9HBJ7|USP29
     1  MISLKVCGFI QIWSQKTGMT KLKEALIETV QRQKEIKLVV TFKSGKFIRI FQLSNNIRSV
    61  VLRHCKKRQS HLRLTLKNNV FLFIDKLSYR DAKQLNMFLD IIHQNKSQQP MKSDDDWSVF
   121  ESRNMLKEID KTSFYSICNK PSYQKMPLFM SKSPTHVKKG ILENQGGKGQ NTLSSDVQTN
   181  EDILKEDNPV PNKKYKTDSL KYIQSNRKNP SSLEDLEKDR DLKLGPSFNT NCNGNPNLDE
   241  TVLATQTLNA KNGLTSPLEP EHSQGDPRCN KAQVPLDSHS QQLQQGFPNL GNTCYMNAVL
   301  QSLFAIPSFA DDLLTQGVPW EYIPFEALIM TLTQLLALKD FCSTKIKREL LGNVKKVISA
   361  VAEIFSGNMQ NDAHEFLGQC LDQLKEDMEK LNATLNTGKE CGDENSSPQM HVGSAATKVF
   421  VCPVVANFEF ELQLSLICKA CGHAVLKVEP NNYLSINLHQ ETKPLPLSIQ NSLDLFFKEE
   481  ELEYNCQMCK QKSCVARHTF SRLSRVLIIH LKRYSFNNAW LLVKNNEQVY IPKSLSLSSY
   541  CNESTKPPLP LSSSAPVGKC EVLEVSQEMI SEINSPLTPS MKLTSESSDS LVLPVEPDKN
   601  ADLQRFQRDC GDASQEQHQR DLENGSALES ELVHFRDRAI GEKELPVADS LMDQGDISLP
   661  VMYEDGGKLI SSPDTRLVEV HLQEVPQHPE LQKYEKTNTF VEFNFDSVTE STNGFYDCKE
   721  NRIPEGSQGM AEQLQQCIEE SIIDEFLQQA PPPGVRKLDA QEHTEETLNQ STELRLQKAD
   781  LNHLGALGSD NPGNKNILDA ENTRGEAKEL TRNVKMGDPL QAYRLISVVS HIGSSPNSGH
   841  YISDVYDFQK QAWFTYNDLC VSEISETKMQ EARLHSGYIF FYMHNGIFEE LLRKAENSRL
   901  PSTQAGVIPQ GEYEGDSLYR PA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

testis: 4.6 nTPM
bone marrow: 1.5 nTPM
pancreas: 1.2 nTPM
skin: 0.9 nTPM
choroid plexus: 0.3 nTPM
heart muscle: 0.3 nTPM

Single-cell type

early primary spermatocytes: 6.9 nCPM
late primary spermatocytes: 6.2 nCPM
differentiating spermatogonia: 3.1 nCPM
early spermatids: 2.8 nCPM
undifferentiated spermatogonia: 2.3 nCPM
foveolar cells: 1.2 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 0.8 nTPM
eosinophil: 0.3 nTPM
plasmacytoid DC: 0.3 nTPM
classical monocyte: 0.2 nTPM
intermediate monocyte: 0.2 nTPM

Brain region

cerebellum: 9 nTPM
medulla oblongata: 8.8 nTPM
midbrain: 7.8 nTPM
hypothalamus: 7.6 nTPM
white matter: 7.6 nTPM
choroid plexus: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.08
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP29 as an antibody target. Whether an autoantibody or antibody against USP29 could matter depends on whether native USP29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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