Seroatlas · Human Serome Atlas

USP17L4

Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4

Also known as: U17L4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCW7
Gene: USP17L4
Ensembl: ENSG00000236125
Chromosome: 8
Canonical length: 530 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>A6NCW7|USP17L4
     1  MGDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSSETRVD LCDDLAPVAR
    61  QLAPREKLPL SSRRPAAVGA GLQNMGNTCY ENASLQCLTY TLPLANYMLS REHSQTCQRP
   121  KCCMLCTMQA HITWALHSPG HVIQPSQALA AGFHRGKQED VHEFLMFTVD AMKKACLPGH
   181  KQVDHHSKDT TLIHQIFGGC WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVKQALEQL
   241  VKPEELNGEN AYHCGLCLQR APASNTLTLH TSAKVLILVL KRFSDVAGNK LAKNVQYPEC
   301  LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HDGYYFSYVK AQEGQWYKMD DAEVTVCSIT
   361  SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD RPATQGELKR DHPCLQVPEL
   421  DEHLVERATE ESTLDHWKFP QEQNKMKPEF NVRKVEGTLP PNVLVIHQSK YKCGMKNHHP
   481  EQQSSLLNLS SMNSTDQESM NTGTLASLQG RTRRSKGKNK HSKRSLLVCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP17L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

cardiomyocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 3.3 nTPM
cerebral cortex: 3 nTPM
pons: 2.6 nTPM
medulla oblongata: 2.5 nTPM
basal ganglia: 2.2 nTPM
hippocampal formation: 2.1 nTPM

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP17L4 as an antibody target. Whether an autoantibody or antibody against USP17L4 could matter depends on whether native USP17L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP17L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP17L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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