Seroatlas · Human Serome Atlas

USP17L10

Ubiquitin carboxyl-terminal hydrolase 17-like protein 10

Also known as: U17LA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JJH3
Gene: USP17L10
Ensembl: ENSG00000231396
Chromosome: 4
Canonical length: 530 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of apoptotic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

530 residues, UniProt reviewed canonical sequence.

>C9JJH3|USP17L10
     1  MEDDSLYLGG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD LCDDLAPVAR
    61  QLAPREKPPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY KPPLANYMLF REHSQTCHRH
   121  KGCMLCTMQA HITRALHIPG HVIQPSQALA AGFHRGKQED AHEFLMFTVD AMRKACLPGH
   181  KQVDRHSKDT TLIHQIFGGY WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL
   241  VKPEELNGEN AYHCGVCLQR APASKTLTLH NSAKVLILVL KRFPDVTGNK IAKNVQYPEC
   301  LDMQPYMSQQ NTGPLVYVLY AVLVHAGWSC HNGHYSSYVK AQEGQWYKMD DAEVTASSIT
   361  SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGVEDTD RRATQGELKR DHPCLQAPEL
   421  DEHLVERATQ ESTLDHWKFL QEQNKTKPEF NVRRVEGTVP PDVLVIHQSK YKCRMKNHHP
   481  EQQSSLLNLS STTPTDQESM NTGTLASLRG RTRRSKGKNK HSKRALLVCQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USP17L10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -7.99
DepMap mean gene effect: -0.17
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

cysteine-type deubiquitinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads USP17L10 as an antibody target. Whether an autoantibody or antibody against USP17L10 could matter depends on whether native USP17L10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

USP17L10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label USP17L10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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