USF3

Protein identityUniProt · HPA

UniProt accession

Q68DE3

Gene

USF3

Ensembl

ENSG00000176542

Chromosome

3

Canonical length

2245 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli,Centrosome

OverviewNCBI Gene

This gene encodes a large protein that contains a helix-loop-helix domain and a polyglutamine region. A deletion in the polyglutamine region was associated with risk for thyroid carcinoma. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

2245 residues, UniProt reviewed canonical sequence.

>Q68DE3|USF3
     1  MPEMTENETP TKKQHRKKNR ETHNAVERHR KKKINAGINR IGELIPCSPA LKQSKNMILD
    61  QAFKYITELK RQNDELLLNG GNNEQAEEIK KLRKQLEEIQ KENGRYIELL KANDICLYDD
   121  PTIHWKGNLK NSKVSVVIPS DQVQKKIIVY SNGNQPGGNS QGTAVQGITF NVSHNLQKQT
   181  ANVVPVQRTC NLVTPVSISG VYPSENKPWH QTTVPALATN QPVPLCLPAA ISAQSILELP
   241  TSESESNVLG ATSGSLIAVS IESEPHQHHS LHTCLNDQNS SENKNGQENP KVLKKMTPCV
   301  TNIPHSSSAT ATKVHHGNKS CLSIQDFRGD FQNTFVVSVT TTVCSQPPRT AGDSSPMSIS
   361  KSADLTSTAT VVASSAPGVG KATIPISTLS GNPLDNGWTL SCSLPSSSVS TSDLKNINSL
   421  TRISSAGNTQ TTWTTLQLAG NTIQPLSQTP SSAVTPVLNE SGTSPTTSNH SRYVATDINL
   481  NNSFPADGQP VEQVVVTLPS CPSLPMQPLI AQPQVKSQPP KNILPLNSAM QVIQMAQPVG
   541  SAVNSAPTNQ NVIILQPPST TPCPTVMRAE VSNQTVGQQI VIIQAANQNP LPLLPAPPPG
   601  SVRLPINGAN TVIGSNNSVQ NVPTPQTFGG KHLVHILPRP SSLSASNSTQ TFSVTMSNQQ
   661  PQTISLNGQL FALQPVMSSS GTTNQTPMQI IQPTTSEDPN TNVALNTFGA LASLNQSISQ
   721  MAGQSCVQLS ISQPANSQTA ANSQTTTANC VSLTTTAAPP VTTDSSATLA STYNLVSTSS
   781  MNTVACLPNM KSKRLNKKPG GRKHLAANKS ACPLNSVRDV SKLDCPNTEG SAEPPCNDGL
   841  LESFPAVLPS VSVSQANSVS VSASHSLGVL SSESLIPESV SKSKSAEKSS PPSQESVTSE
   901  HFAMAAAKSK DSTPNLQQET SQDKPPSSLA LSDAAKPCAS ANVLIPSPSD PHILVSQVPG
   961  LSSTTSTTST DCVSEVEIIA EPCRVEQDSS DTMQTTGLLK GQGLTTLLSD LAKKKNPQKS
  1021  SLSDQMDHPD FSSENPKIVD SSVNLHPKQE LLLMNNDDRD PPQHHSCLPD QEVINGSLIN
  1081  GRQADSPMST SSGSSRSFSV ASMLPETTRE DVTSNATTNT CDSCTFVEQT DIVALAARAI
  1141  FDQENLEKGR VGLQADIREV ASKPSEASLL EGDPPFKSQI PKESGTGQAE ATPNEFNSQG
  1201  SIEATMERPL EKPSCSLGIK TSNASLQDST SQPPSITSLS VNNLIHQSSI SHPLASCAGL
  1261  SPTSEQTTVP ATVNLTVSSS SYGSQPPGPS LMTEYSQEQL NTMTSTIPNS QIQEPLLKPS
  1321  HESRKDSAKR AVQDDLLLSS AKRQKHCQPA PLRLESMSLM SRTPDTISDQ TQMMVSQIPP
  1381  NSSNSVVPVS NPAHGDGLTR LFPPSNNFVT PALRQTEVQC GSQPSVAEQQ QTQASQHLQA
  1441  LQQHVPAQGV SHLHSNHLYI KQQQQQQQQQ QQQQQQQQAG QLRERHHLYQ MQHHVPHAES
  1501  SVHSQPHNVH QQRTLQQEVQ MQKKRNLVQG TQTSQLSLQP KHHGTDQSRS KTGQPHPHHQ
  1561  QMQQQMQQHF GSSQTEKSCE NPSTSRNHHN HPQNHLNQDI MHQQQDVGSR QQGSGVSSEH
  1621  VSGHNPMQRL LTSRGLEQQM VSQPSIVTRS SDMTCTPHRP ERNRVSSYSA EALIGKTSSN
  1681  SEQRMGISIQ GSRVSDQLEM RSYLDVPRNK SLAIHNMQGR VDHTVASDIR LSDCQTFKPS
  1741  GASQQPQSNF EVQSSRNNEI GNPVSSLRSM QSQAFRISQN TGPPPIDRQK RLSYPPVQSI
  1801  PTGNGIPSRD SENTCHQSFM QSLLAPHLSD QVIGSQRSLS EHQRNTQCGP SSAIEYNCPP
  1861  THENVHIRRE SESQNRESCD MSLGAINTRN STLNIPFSSS SSSGDIQGRN TSPNVSVQKS
  1921  NPMRITESHA TKGHMNPPVT TNMHGVARPA LPHPSVSHGN GDQGPAVRQA NSSVPQRSRH
  1981  PLQDSSGSKI RQPERNRSGN QRQSTVFDPS LPHLPLSTGG SMILGRQQPA TEKRGSIVRF
  2041  MPDSPQVPND NSGPDQHTLS QNFGFSFIPE GGMNPPINAN ASFIPQVTQP SATRTPALIP
  2101  VDPQNTLPSF YPPYSPAHPT LSNDISIPYF PNQMFSNPST EKVNSGSLNN RFGSILSPPR
  2161  PVGFAQPSFP LLPDMPPMHM TNSHLSNFNM TSLFPEIATA LPDGSAMSPL LTIANSSASD
  2221  SSKQSSNRPA HNISHILGHD CSSAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against USF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

18 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about USF3.

Disease | ImmuneIEDB

Conditions an epitope on USF3 was assayed in.

• human immunodeficiency virus infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.19

gnomAD pLI

1

DepMap mean gene effect

0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• negative regulation of epithelial to mesenchymal transition
• positive regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• protein dimerization activity
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• nucleus

Protein domainsUniProt · Pfam · InterPro

• Myc-type, basic helix-loop-helix (bHLH) domain
• Helix-loop-helix DNA-binding domain superfamily
• Helix-loop-helix DNA-binding domain
• Upstream transcription factor 3, basic helix-loop-helix domain
• Epithelial-mesenchymal transition regulator

KeywordsUniProt

• Coiled coil
• DNA-binding
• Nucleus