URM1
Ubiquitin-related modifier 1
Also known as: C9orf74, MGC2668, URM1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BTM9
- Gene
- URM1
- Ensembl
- ENSG00000167118
- Chromosome
- 9
- Canonical length
- 101 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Enables sulfur carrier activity. Involved in tRNA thio-modification and tRNA wobble uridine modification. Predicted to be located in cytosol. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
101 residues, UniProt reviewed canonical sequence.
>Q9BTM9|URM1
1 MAAPLSVEVE FGGGAELLFD GIKKHRVTLP GQEEPWDIRN LLIWIKKNLL KERPELFIQG
61 DSVRPGILVL INDADWELLG ELDYQLQDQD SVLFISTLHG GLocalizationUniProt · AlphaFold · HPA
Whether an antibody against URM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 32 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 32 nTPM
- pancreas: 32 nTPM
- spleen: 30 nTPM
- spinal cord: 30 nTPM
- kidney: 28 nTPM
- midbrain: 28 nTPM
Single-cell type
- esophageal basal cells: 132 nCPM
- extravillous trophoblasts: 126 nCPM
- migrating cytotrophoblasts: 126 nCPM
- cytotrophoblasts: 115 nCPM
- decidual stromal cells: 113 nCPM
- esophageal suprabasal cells: 112 nCPM
Immune cell
- intermediate monocyte: 18 nTPM
- non-classical monocyte: 18 nTPM
- myeloid DC: 17 nTPM
- T-reg: 16 nTPM
- gdT-cell: 15 nTPM
- classical monocyte: 14 nTPM
Brain region
- white matter: 45 nTPM
- midbrain: 44 nTPM
- medulla oblongata: 43 nTPM
- basal ganglia: 42 nTPM
- thalamus: 39 nTPM
- cerebral cortex: 38 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.27
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.43
- DepMap mean gene effect
- -0.71
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Beta-grasp domain superfamily
- Ubiquitin-related modifier 1
- Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp
- Urm1 (Ubiquitin related modifier)
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of URM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads URM1 as an antibody target. Whether an autoantibody or antibody against URM1 could matter depends on whether native URM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
URM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label URM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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