Seroatlas · Human Serome Atlas

URB2

Unhealthy ribosome biogenesis protein 2 homolog

Also known as: KIAA0133, NET10, NPA2, URB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14146
Gene: URB2
Ensembl: ENSG00000135763
Chromosome: 1
Canonical length: 1524 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to be involved in regulation of signal transduction by p53 class mediator and ribosome biogenesis. Located in aggresome; midbody; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1524 residues, UniProt reviewed canonical sequence.

>Q14146|URB2
     1  MAAVYSGISL KLKSKTTSWE DKLKLAHFAW ISHQCFLPNK EQVLLDWARQ SLVAFYKKKL
    61  ELKEDIVERL WIYIDNILHS RKLQNLLKNG KTINLQISLV KIINERVAEF SLSGSQRNIC
   121  AVLRCCQGIL STPALAVIYT AKQELMVALL SQLCWSACRQ PEGAVVAQLF EVIHLALGHY
   181  LLILQQQVNP RRAFGDVTAH LLQPCLVLRH LLSGGTWTQA GQGQLRQVLS RDIRSQIEAM
   241  FRGGIFQPEL LSSYKEGLLD QQQGDVKTGA MKNLLAPMDT VLNRLVDAGY CAASLHTSVV
   301  ANSVALLYKL FLDSYFKEGN QLLCFQVLPR LFGCLKISHL QEEQSKALST SDWTTELLVV
   361  EQLLNSVANN NIYNIAADRI RHEEAQFRFY RHVAELLINH AQAPIPAWFR CLKTLISLNH
   421  LILEPDLDDL LASAWIDAEV TEFRTKKAQE ALIRTVFQTY AKLRQVPRLF EEVLGVICRP
   481  AAEALRQPVL ASGPSTVLSA CLLELPPSQI LDTWSLVLEK FQSLVLPYLQ SDADMALKSL
   541  SLSLLLHCIM FNMRSLDSST PLPIVRRTQC MMERMMRELV QPLLALLPDT PGPEPELWLQ
   601  KVSDSVLLLS YTWAQVDAMF SLNCSQYHSM SGPLIGVALE ISNLPSLLPG VKTQHWKKIE
   661  KFTAQFSSLG TYCLEQLYLQ KMKRTLMQTS FRSEGAIQSL RCDAAFIIGS GRKSLNQRTT
   721  ASWDGQVGMV SGLTYPVAHW HLIVSNLTIL ISYLCPDDVG YLASVLLRTL PMGKAQEVSI
   781  DEEAYITLEK ISKAFLHSPL FPEMQSLHSA FLTCVTTSCS SILCSGAQRD SGLVSQQLPW
   841  LFEKDHMVVG HWENRFAKAG PEGIEPRGEI AQNLLSLVKS DFPIQLEGEQ LESILGLLEV
   901  ISALQLDSLL PPYHVHYFLV LLSMAVTKLG CSCSSSLALK FLTTCYQLLG YLQKGKSARS
   961  VFKIMYGSDI FEVVLTSLFR ASSRFLIEMD DPAWLEFLQV IGTFLEELMQ MLIQMKLSLV
  1021  LNFRKITAFL SSSKPYTEAA SSKQLENQNP QGRQLLLVSL TRLCHVLGPF LKEQKLGQEA
  1081  PAALSELLQQ VVLQTGAVLQ LCSVPGARGW RLPSVLISSV STLLEADLGQ HCRDGGADIS
  1141  QGSDRTLLSH VALYQGVYSQ ILLELPALAG HDQSFQAALQ FLTLFFLAPE LHPKKDSVFT
  1201  SMFHSVRRVL ADPEIPVQVT QDIEPHLGAL FTQMLEVGTT EDLRLVMQCI LQGLDVSNMW
  1261  KADVQAVVSA VTLLRLLLNC PLSGEKASLL WRACPQIVTA LTLLNREASQ EQPVSLTVVG
  1321  PVLDVLAALL RQGEEAIGNP HHVSLAFSIL LTVPLDHLKP LEYGSVFPRL HNVLFSILQC
  1381  HPKVMLKAIP SFLNSFNRLV FSVMREGRQK DKGSIDDLPT VLKCARLVER MYSHIAARAE
  1441  EFAVFSPFMV AQYVLEVQKV TLYPAVKSLL QEGIYLILDL CIEPDVQFLR ASLQPGMRDI
  1501  FKELYNDYLK YHKAKHEGEK RYTA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against URB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6.4 nTPM
testis: 5.4 nTPM
adipose tissue: 4.6 nTPM
urinary bladder: 4.6 nTPM
pancreas: 4.4 nTPM
tonsil: 4.4 nTPM

Single-cell type

corticotrophs: 33 nCPM
erythrocyte progenitors: 30 nCPM
adipocytes: 23 nCPM
extravillous trophoblasts: 23 nCPM
rod photoreceptor cells: 22 nCPM
myonuclei: 20 nCPM

Immune cell

MAIT T-cell: 2.2 nTPM
intermediate monocyte: 1.7 nTPM
naive CD4 T-cell: 1.6 nTPM
memory CD8 T-cell: 1.4 nTPM
T-reg: 1.4 nTPM
total PBMC: 1.4 nTPM

Brain region

white matter: 8.1 nTPM
spinal cord: 7.6 nTPM
medulla oblongata: 7.5 nTPM
midbrain: 7.5 nTPM
cerebellum: 7.4 nTPM
thalamus: 7.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: -0.38
DepMap mean gene effect: -0.96
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal
Ribosome Biogenesis Regulator
Urb2/Npa2 family

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads URB2 as an antibody target. Whether an autoantibody or antibody against URB2 could matter depends on whether native URB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

URB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label URB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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