Seroatlas · Human Serome Atlas

URB1

Nucleolar pre-ribosomal-associated protein 1

Also known as: C21orf108, KIAA0539, NPA1, NPA1P_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60287
Gene: URB1
Ensembl: ENSG00000142207
Chromosome: 21
Canonical length: 2271 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Enables RNA binding activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2271 residues, UniProt reviewed canonical sequence.

>O60287|URB1
     1  MGVPKRKASG GQDGAASSAG AAKRARKEEL TGVRFKAQLK DPQGPGPGLE AFVSAAKKLP
    61  REDVYDVVEG YIKISVECVE IFQLLSGEKR PESETMLIFQ VFEAILLRTA SDLSHFHVVG
   121  TNIVKKLMNN HMKLICESLY ASGYRLARAC LSLMTAMVTQ GPEAARDVCS HFDLNKKTLY
   181  TLVTKRDSKG VYDVRQAYVQ FALSFLIAGD DSTIVQVLEV KEFIPCIFSS GIKEDRISTI
   241  NILLSTLKTK VVHNKNITKT QKVRFFTGQL LNHIASLYNW NGITDVNPEN VKVSAEEAGK
   301  TMVRELVHNF LMDLCCSLKH GINFYDASLG TFGRGGNLTL LHFLLGLKTA ADDDLVADLV
   361  VNILKVCPDL LNKYFKEVTF SFIPRAKSTW LNNIKLLNKI YEAQPEISRA FQTREFIPLP
   421  RLLAMVMVTT VPLVCNKSMF TQALNLDSTS VRHTALSLIS VILKRALKTV DHCLNKEVWQ
   481  ESGVYTAVMM EEFVQLFREA LSKILPDLNT VVWVWQSLKK QETKQDDKKG QKRSDGPPAA
   541  CDAHQCDDAE TILLKAVLLQ VICLYQKVVP HVVMQYNFDF SKLLKGVISE QGLREEVPPI
   601  LQHHMLKVAL ELPASKFLWL KAQEGPDAEI IGGERSVFYL LMKMFVTSSH LQLKSLTKLL
   661  IMKILRDTGV FEHTWKELEL WLEHLENTME EDKETVIQFL ERILLTLVAN PYSYTDKASD
   721  FVQEASMLQA TMTKQEADDM SIPISHIDDV LDMVDVLVEG SEGLDEEIGF TLSEDMILLT
   781  FPFSAVVPAA LEARNKLLLG TGNEAAENVV TYLTAVLTDL LHTQRDPLAL CLLLQAYDKL
   841  EPPCLVPCCQ QLSRFNRYYS LWIPEQAREA WLLQAQGSPS PPALPLASSF TALLQAAYES
   901  QALRDEHIQV QLQATMPHLS MQQVLLAAKQ VLLYLRSTVE NFGQLGRSVG PPLLQLFLDL
   961  LRRLVVHCEQ LDAQNQQRCE AARAEADLFL DMESVASLEL ANDQTLEEVL VAILRHPTLE
  1021  GWFLALEQQA LPPHTLSPVL VKLLATHFSA GVLQLLAASA PILQNIGQLG LLARYSEAIT
  1081  QSVLKELQNR RAGPATSPPK TPPQLEALQE LHPYMEGAQL REVTLALLSL PETHLVTQQP
  1141  TKSPGKERHL NALGKTLVQL LTCSPQDQLQ SGELLWSSEY VRGLGALLPT LAVDELDTVL
  1201  LHTLQRDPVL APAVGADLLD YCLARRTQAA LSIAALLLQE SCTHLLWFEQ WCLQAGPGLG
  1261  LQGDLDDFLP LIHVYLQCRT RSHFTRPAGV SSAVIPVLRK TLWRQLQSRL LSTDSPPASG
  1321  LYQEILAQLV PFARAKDLSV LMDRLPSLLH TPSSHKRWIV ADSISAALEG SAEELCAWRR
  1381  TLLESCVKWL IVSFSGGQQD DDNTQNQEKE MLLRLNALLH ALNEVDPGDW QKFVKKGLKF
  1441  RYQDHTFLKM LLTAVQLLYS PESSVRTKLI QLPVVYVMLM QHSLFLPTLL TSDGEESPDS
  1501  QVKEALVDLM LTVVEMCPSV CESSHFAVLL GAYGATLSVL DQKILLLLRA YEQNKLSLIN
  1561  FRVLLWGPAA VEHHKTCRSL GRSLWQQPSV GDILRLLDRD RMMQTILHFP QNRRLLPPED
  1621  TQELIFKDKS RVDLDGLYDP CFLLQLFSEL TRPEFVVDCR KFLDSNALGL TVTALSSYDP
  1681  QMRAIAYHVL AAYYSHLEGA RFQEQSQLLY LLDVVRNGIR TQDMRLTFTL ALFIAKAALQ
  1741  ILKPEEHMYL KVSNFLLSHE YLNMDKVPGF YQFFYSSDFE QKTEQKWVFG VLRQGIRDKQ
  1801  CYELCARRGI FHIILSFFHS PLCDEAAQNW ILEILQNAAQ VARSAYEIIR DYSLLTWILH
  1861  ILESKFLETP LLSNVISLLH TLWVTNLGDK AVEWESQRLC QPSSQEPAKR LALHLVNEFL
  1921  YVLIVLMKHL RPTLAPVQLT NFFGTLDSVL RYRATVIQAF RDMNRFTVNE TVLSTKDVLV
  1981  LLHKWSLIER DLKLQEDLRA AIEKAQAREL MKMLKDKNKP VMPARAKGPR GRKRRPGEAE
  2041  EMADPELMAS TLETCKGLLR SILTYWRPVI PGPDPTQEPV DSASPESDAP GPVYAAASLA
  2101  VSWVLRSVAE HPLSRAEAAG LIGWLKSHIL PHPVVVADLL KDSAVRSSIF RLYSRLCGAE
  2161  GLAGPVQEVA CLFNTVMLQL VAAQGRAGSP FHPAMEALSL SSLSEKDEAT QASAAFLVSL
  2221  YIKDIWLGAQ RPDTLLTHVR MVCEAADDAP SSEEEAIVVL CKDAASAASD A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against URB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

endometrium: 10 nTPM
prostate: 9.3 nTPM
blood vessel: 9.1 nTPM
skeletal muscle: 8.3 nTPM
urinary bladder: 7.7 nTPM
choroid plexus: 7.5 nTPM

Single-cell type

endometrial ciliated cells: 137 nCPM
prostatic glandular cells: 121 nCPM
respiratory secretory cells: 102 nCPM
respiratory deuterosomal cells: 91 nCPM
adrenal cortex cells: 86 nCPM
endometrial glandular cells: 83 nCPM

Immune cell

basophil: 0.9 nTPM
MAIT T-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
memory B-cell: 0.6 nTPM
naive CD4 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM

Brain region

choroid plexus: 38 nTPM
medulla oblongata: 22 nTPM
pons: 21 nTPM
hippocampal formation: 19 nTPM
white matter: 19 nTPM
midbrain: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about URB1.

Disease | ImmuneIEDB

Conditions an epitope on URB1 was assayed in.

stomach cancer T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0
gnomAD missense Z: 2.09
DepMap mean gene effect: -0.97
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Armadillo-type fold
URB1, N-terminal
URB1, C-terminal domain
Nucleolar pre-ribosomal-associated protein 1
URB1, central HEAT repeat domain
Ribosome 60S biogenesis N-terminal
Nucleolar pre-ribosomal-associated protein 1
URB1, central HEAT repeat domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads URB1 as an antibody target. Whether an autoantibody or antibody against URB1 could matter depends on whether native URB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

URB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label URB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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