Seroatlas · Human Serome Atlas

UQCRHL

Cytochrome b-c1 complex subunit 6-like, mitochondrial

Also known as: QCR6L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A096LP55
Gene
UQCRHL
Ensembl
ENSG00000233954
Chromosome
1
Canonical length
91 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene has characteristics of a pseudogene derived from the UQCRH gene. However, there is still an open reading frame that could produce a protein of the same or nearly the same size as that of the UQCRH gene, so this gene is being called protein-coding for now. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

91 residues, UniProt reviewed canonical sequence.

>A0A096LP55|UQCRHL
     1  MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELYDEHVSSR
    61  SHTEEDCTEE LFDFLHAKDH CVAHKLFNNL K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UQCRHL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 16 nTPM
  • skeletal muscle: 10 nTPM
  • cerebellum: 6.4 nTPM
  • cerebral cortex: 6.2 nTPM
  • kidney: 5.7 nTPM
  • retina: 5.3 nTPM

Single-cell type

  • esophageal suprabasal cells: 19 nCPM
  • megakaryocytes: 19 nCPM
  • esophageal apical cells: 17 nCPM
  • esophageal basal cells: 15 nCPM
  • endometrial secretory cells: 11 nCPM
  • medullary thymic epithelial cells: 9.6 nCPM

Immune cell

  • neutrophil: 2.4 nTPM
  • basophil: 1.8 nTPM
  • gdT-cell: 0.6 nTPM
  • naive B-cell: 0.6 nTPM
  • total PBMC: 0.6 nTPM
  • eosinophil: 0.5 nTPM

Brain region

  • cerebellum: 10 nTPM
  • white matter: 8.8 nTPM
  • pons: 7.7 nTPM
  • cerebral cortex: 7.6 nTPM
  • medulla oblongata: 7.6 nTPM
  • thalamus: 7.3 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UQCRHL as an antibody target. Whether an autoantibody or antibody against UQCRHL could matter depends on whether native UQCRHL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UQCRHL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UQCRHL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UQCRHL. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...