UQCRH
Cytochrome b-c1 complex subunit 6, mitochondrial
Also known as: QCR6, QCR6_HUMAN, UQCR8
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P07919
- Gene
- UQCRH
- Ensembl
- ENSG00000173660
- Chromosome
- 1
- Canonical length
- 91 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
OverviewNCBI Gene
Enables ubiquinol-cytochrome-c reductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial inner membrane. Implicated in mitochondrial complex III deficiency. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
91 residues, UniProt reviewed canonical sequence.
>P07919|UQCRH
1 MGLEDEQKML TESGDPEEEE EEEEELVDPL TTVREQCEQL EKCVKARERL ELCDERVSSR
61 SHTEEDCTEE LFDFLHARDH CVAHKLFNNL KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UQCRH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 1,100 nTPM
Expression across tissuesHPA
Tissue
- heart muscle: 1,100 nTPM
- tongue: 963 nTPM
- skeletal muscle: 874 nTPM
- choroid plexus: 512 nTPM
- cerebral cortex: 446 nTPM
- kidney: 424 nTPM
Single-cell type
- parietal cells: 3,255 nCPM
- megakaryocytes: 2,510 nCPM
- esophageal suprabasal cells: 2,173 nCPM
- esophageal apical cells: 1,944 nCPM
- gastric progenitor cells: 1,666 nCPM
- esophageal basal cells: 1,665 nCPM
Immune cell
- total PBMC: 622 nTPM
- memory B-cell: 547 nTPM
- myeloid DC: 483 nTPM
- naive B-cell: 436 nTPM
- classical monocyte: 374 nTPM
- naive CD4 T-cell: 347 nTPM
Brain region
- cerebral cortex: 149 nTPM
- choroid plexus: 140 nTPM
- hypothalamus: 135 nTPM
- cerebellum: 134 nTPM
- thalamus: 132 nTPM
- medulla oblongata: 127 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about UQCRH.
Disease | AllUniProt
Conditions UQCRH is implicated in, by any mechanism.
- Mitochondrial complex III deficiency, nuclear type 11 (MC3DN11) MIM:620137
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 24 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Mitochondrial complex III deficiency, nuclear type 11
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.35
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.17
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- aerobic respiration
- cellular respiration
- mitochondrial electron transport, ubiquinol to cytochrome c
- oxidative phosphorylation
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UQCRH as an antibody target. Whether an autoantibody or antibody against UQCRH could matter depends on whether native UQCRH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UQCRH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UQCRH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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