UQCRFS1P1
Putative cytochrome b-c1 complex subunit Rieske-like protein 1
Also known as: UCRIL_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for UQCRFS1P1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
283 residues, UniProt reviewed canonical sequence.
>P0C7P4|UQCRFS1P1
1 MQQIYTVKEI RSVAARSGPF APVLSATSRG VAGALRPLVQ ATVPATPEQP VLDLKRPFLS
61 RESLSGQAVR RPLVASVGLN VPASVCYSHT DIKVPDFSEY RRLEVLDSTK SSRESTEARK
121 GFSYLVTGVT TVGVAYAAKN AVTQFVSSMS ASADVLALAK IEIKLSDIPE GKNMAFKWRG
181 KPLFVRHRTQ KEIKQEAAVE LSQLRDPQHD LDRVKKPEWV ILIGVCTHLG CVPIANAGDF
241 GGYYCPCHGS HYDASGRIRL GPATLNLEVP TYEFTSDDMV IVGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UQCRFS1P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.46
OntologyGO
Biological processes
- ubiquinol to cytochrome c
- mitochondrial electron transport
Molecular functions
- 2 iron, 2 sulfur cluster binding
- metal ion binding
- oxidoreductase activity
- quinol-cytochrome-c reductase activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cytochrome b-c1 complex subunit Rieske, transmembrane domain
- Rieske iron-sulphur protein, C-terminal
- Ubiquinol-cytochrome c reductase, iron-sulphur subunit
- Globular protein, non-globular alpha/beta subunit
- Rieske iron-sulphur protein
- Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal
- Rieske [2Fe-2S] iron-sulphur domain
- Rieske [2Fe-2S] iron-sulphur domain superfamily
- Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily
- Rieske [2Fe-2S] domain
- Ubiquinol cytochrome reductase transmembrane region
- Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UQCRFS1P1 as an antibody target. Whether an autoantibody or antibody against UQCRFS1P1 could matter depends on whether native UQCRFS1P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UQCRFS1P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UQCRFS1P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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