UQCR11
Cytochrome b-c1 complex subunit 10
Also known as: QCR10, QCR10_HUMAN, UQCR
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O14957
- Gene
- UQCR11
- Ensembl
- ENSG00000127540
- Chromosome
- 19
- Canonical length
- 56 aa
- Protein class
- Metabolic proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes the smallest known component of the ubiquinol-cytochrome c reductase complex, which forms part of the mitochondrial respiratory chain. The encoded protein may function as a binding factor for the iron-sulfur protein in this complex. [provided by RefSeq, Oct 2009]
Canonical amino-acid sequenceUniProt
56 residues, UniProt reviewed canonical sequence.
>O14957|UQCR11
1 MVTRFLGPRY RELVKNWVPT AYTWGAVGAV GLVWATDWRL ILDWVPYING KFKKDNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UQCR11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 292 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 292 nTPM
- heart muscle: 267 nTPM
- amygdala: 133 nTPM
- liver: 123 nTPM
- kidney: 119 nTPM
- midbrain: 119 nTPM
Single-cell type
- parietal cells: 2,498 nCPM
- hepatocytes: 1,831 nCPM
- enterocytes: 1,551 nCPM
- colonocytes: 1,421 nCPM
- hofbauer cells: 912 nCPM
- epididymal principal cells: 862 nCPM
Immune cell
- total PBMC: 874 nTPM
- basophil: 623 nTPM
- eosinophil: 524 nTPM
- neutrophil: 499 nTPM
- plasmacytoid DC: 449 nTPM
- classical monocyte: 423 nTPM
Brain region
- cerebellum: 61 nTPM
- basal ganglia: 60 nTPM
- thalamus: 60 nTPM
- choroid plexus: 59 nTPM
- midbrain: 58 nTPM
- white matter: 57 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.94
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.41
- DepMap mean gene effect
- -0.31
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- cellular respiration
- generation of precursor metabolites and energy
- mitochondrial electron transport, ubiquinol to cytochrome c
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cytochrome b-c1 complex subunit 10
- Single alpha-helix domain superfamily
- Ubiquinol-cytochrome C reductase complex, 6.4kD protein
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UQCR11 as an antibody target. Whether an autoantibody or antibody against UQCR11 could matter depends on whether native UQCR11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UQCR11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UQCR11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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