Seroatlas · Human Serome Atlas

UPP2

Uridine phosphorylase 2

Also known as: UDRPASE2, UP2, UPASE2, UPP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95045
Gene: UPP2
Ensembl: ENSG00000007001
Chromosome: 2
Canonical length: 317 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Mitochondria
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables deoxyuridine phosphorylase activity; identical protein binding activity; and uridine phosphorylase activity. Involved in dCMP catabolic process and uridine catabolic process. Located in type III intermediate filament. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>O95045|UPP2
     1  MASVIPASNR SMRSDRNTYV GKRFVHVKNP YLDLMDEDIL YHLDLGTKTH NLPAMFGDVK
    61  FVCVGGSPNR MKAFALFMHK ELGFEEAEED IKDICAGTDR YCMYKTGPVL AISHGMGIPS
   121  ISIMLHELIK LLHHARCCDV TIIRIGTSGG IGIAPGTVVI TDIAVDSFFK PRFEQVILDN
   181  IVTRSTELDK ELSEELFNCS KEIPNFPTLV GHTMCTYDFY EGQGRLDGAL CSFSREKKLD
   241  YLKRAFKAGV RNIEMESTVF AAMCGLCGLK AAVVCVTLLD RLDCDQINLP HDVLVEYQQR
   301  PQLLISNFIR RRLGLCD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

kidney: 43 nTPM
liver: 22 nTPM
basal ganglia: 2.1 nTPM
amygdala: 1.7 nTPM
cerebral cortex: 1.7 nTPM
hippocampal formation: 1.6 nTPM

Single-cell type

bergmann glia: 441 nCPM
adipocytes: 210 nCPM
brain excitatory neurons: 185 nCPM
oligodendrocyte progenitor cells: 178 nCPM
brain inhibitory neurons: 143 nCPM
astrocytes: 139 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hippocampal formation: 8.7 nTPM
amygdala: 7.7 nTPM
cerebral cortex: 7.1 nTPM
basal ganglia: 6.9 nTPM
white matter: 5.7 nTPM
hypothalamus: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.38
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

deoxyuridine phosphorylase activity
identical protein binding
thymidine phosphorylase activity
uridine phosphorylase activity
pyrimidine-nucleoside phosphorylase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPP2 as an antibody target. Whether an autoantibody or antibody against UPP2 could matter depends on whether native UPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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