Seroatlas · Human Serome Atlas

UPP1

Uridine phosphorylase 1

Also known as: UDRPASE, UP, UPASE, UPP, UPP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16831
Gene: UPP1
Ensembl: ENSG00000183696
Chromosome: 7
Canonical length: 310 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a uridine phosphorylase, an enzyme that catalyzes the reversible phosphorylation of uridine (or 2'- deoxyuridine) to uracil and ribose-1-phosphate (or deoxyribose-1-phosphate). The encoded enzyme functions in the degradation and salvage of pyrimidine ribonucleosides. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

310 residues, UniProt reviewed canonical sequence.

>Q16831|UPP1
     1  MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG
    61  SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH
   121  ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG TVVITEQAVD TCFKAEFEQI VLGKRVIRKT
   181  DLNKKLVQEL LLCSAELSEF TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY
   241  AAGVRNIEME SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS
   301  YFIKKKLSKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

esophagus: 42 nTPM
vagina: 21 nTPM
cervix: 17 nTPM
kidney: 13 nTPM
bone marrow: 12 nTPM
spleen: 11 nTPM

Single-cell type

esophageal apical cells: 2,390 nCPM
neutrophils: 487 nCPM
monocytes: 463 nCPM
esophageal suprabasal cells: 458 nCPM
extravillous trophoblasts: 372 nCPM
ocular epithelial cells: 298 nCPM

Immune cell

classical monocyte: 16 nTPM
non-classical monocyte: 15 nTPM
eosinophil: 12 nTPM
intermediate monocyte: 12 nTPM
gdT-cell: 12 nTPM
basophil: 11 nTPM

Brain region

cerebral cortex: 16 nTPM
thalamus: 14 nTPM
basal ganglia: 13 nTPM
pons: 13 nTPM
hypothalamus: 13 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.34
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPP1 as an antibody target. Whether an autoantibody or antibody against UPP1 could matter depends on whether native UPP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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