Seroatlas · Human Serome Atlas

UPK3BL2

Uroplakin-3b-like protein 2

Also known as: UPKL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: E5RIL1
Gene: UPK3BL2
Ensembl: ENSG00000284981
Chromosome: 7
Canonical length: 263 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>E5RIL1|UPK3BL2
     1  MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL
    61  STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL
   121  RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS
   181  SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP
   241  EEAGSVRRYT THLAFSTPAE GAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPK3BL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

spleen: 38 nTPM
esophagus: 36 nTPM
kidney: 32 nTPM
urinary bladder: 27 nTPM
vagina: 25 nTPM
thyroid gland: 25 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
b-cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 0.3 nTPM
choroid plexus: 0.2 nTPM
medulla oblongata: 0.2 nTPM
cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Uroplakin-3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPK3BL2 as an antibody target. Whether an autoantibody or antibody against UPK3BL2 could matter depends on whether native UPK3BL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPK3BL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPK3BL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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