Seroatlas · Human Serome Atlas

UPK3BL1

Uroplakin-3b-like protein 1

Also known as: UPK3BL, UPK3L_HUMAN, UPLP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
B0FP48
Gene
UPK3BL1
Ensembl
ENSG00000267368
Chromosome
7
Canonical length
263 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>B0FP48|UPK3BL1
     1  MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL
    61  STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL
   121  RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS
   181  SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP
   241  EEAGSVRRYT THLAFSTPAE GAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPK3BL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
260 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 260 nTPM
  • vagina: 167 nTPM
  • cervix: 102 nTPM
  • urinary bladder: 97 nTPM
  • tonsil: 95 nTPM
  • spleen: 84 nTPM

Single-cell type

  • ocular epithelial cells: 0.3 nCPM
  • colonocytes: 0.1 nCPM
  • esophageal apical cells: 0.1 nCPM
  • esophageal suprabasal cells: 0.1 nCPM
  • fibro-adipogenic progenitors: 0.1 nCPM
  • goblet cells: 0.1 nCPM

Immune cell

  • basophil: 15 nTPM
  • gdT-cell: 9.1 nTPM
  • plasmacytoid DC: 9 nTPM
  • eosinophil: 8.7 nTPM
  • T-reg: 7.6 nTPM
  • naive CD4 T-cell: 7.4 nTPM

Brain region

  • medulla oblongata: 33 nTPM
  • white matter: 32 nTPM
  • midbrain: 30 nTPM
  • pons: 30 nTPM
  • hippocampal formation: 29 nTPM
  • cerebral cortex: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.85
gnomAD pLI
0.11

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPK3BL1 as an antibody target. Whether an autoantibody or antibody against UPK3BL1 could matter depends on whether native UPK3BL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPK3BL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPK3BL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UPK3BL1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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