Seroatlas · Human Serome Atlas

UPK3B

Uroplakin-3b

Also known as: FLJ32198, MGC10902, p35, UPIIIb, UPK3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BT76
Gene: UPK3B
Ensembl: ENSG00000243566
Chromosome: 7
Canonical length: 320 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

UPK3B is a minor component of the apical plaques of mammalian urothelium that binds and dimerizes with uroplakin-1b (UPK1B; MIM 602380), one of the major conserved urothelium membrane proteins. The other major conserved integral membrane proteins of urothelial plaques are UPK1A (MIM 611557), UPK2 (MIM 611558), and UPK3A (MIM 611559) (Deng et al., 2002 [PubMed 12446744]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

320 residues, UniProt reviewed canonical sequence.

>Q9BT76|UPK3B
     1  MGLPWGQPHL GLQMLLLALN CLRPSLSLGE WGSWMDASSQ TQGAGGPAGV IGPWAPAPLR
    61  LGEAAPGTPT PVSVAHLLSP VATELVPYTP QITAWDLEGK VTATTFSLEQ PRCVFDGLAS
   121  ASDTVWLVVA FSNASRGFQN PETLADIPAS PQLLTDGHYM TLPLSPDQLP CGDPMAGSGG
   181  APVLRVGHDH GCHQQPFCNA PLPGPGPYRE DPRIHRHLAR AAKWQHDRHY LHPLFSGRPP
   241  TLGLLGSLYH ALLQPVVAGG GPGAAADRLL HGQALHDPPH PTQRGRHTAG GLQAWPGPPP
   301  QPQPLAWPLC MGLGEMGRWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPK3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 113 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 113 nTPM
esophagus: 64 nTPM
lung: 48 nTPM
urinary bladder: 34 nTPM
vagina: 11 nTPM
heart muscle: 10 nTPM

Single-cell type

mesothelial cells: 30 nCPM
esophageal apical cells: 28 nCPM
alveolar cells type 1: 22 nCPM
papillary tip epithelial cells: 14 nCPM
urothelial cells: 8.2 nCPM
epicardial cells: 4.5 nCPM

Immune cell

neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 2.1 nTPM
thalamus: 1.4 nTPM
basal ganglia: 1.1 nTPM
cerebral cortex: 1 nTPM
hypothalamus: 0.7 nTPM
midbrain: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: 0.19
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Uroplakin-3

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPK3B as an antibody target. Whether an autoantibody or antibody against UPK3B could matter depends on whether native UPK3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPK3B is annotated at the cell surface, where native UPK3B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label UPK3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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