Seroatlas · Human Serome Atlas

UPK3A

Uroplakin-3a

Also known as: UPK3, UPK3A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75631
Gene: UPK3A
Ensembl: ENSG00000100373
Chromosome: 22
Canonical length: 287 aa
Protein class: Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location: Nuclear membrane,Nuclear bodies

OverviewNCBI Gene

This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>O75631|UPK3A
     1  MPPLWALLAL GCLRFGSAVN LQPQLASVTF ATNNPTLTTV ALEKPLCMFD SKEALTGTHE
    61  VYLYVLVDSA ISRNASVQDS TNTPLGSTFL QTEGGRTGPY KAVAFDLIPC SDLPSLDAIG
   121  DVSKASQILN AYLVRVGANG TCLWDPNFQG LCNAPLSAAT EYRFKYVLVN MSTGLVEDQT
   181  LWSDPIRTNQ LTPYSTIDTW PGRRSGGMIV ITSILGSLPF FLLVGFAGAI ALSLVDMGSS
   241  DGETTHDSQI TQEAVPKSLG ASESSYTSVN RGPPLDRAEV YSSKLQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UPK3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 39 nTPM
skeletal muscle: 33 nTPM
prostate: 21 nTPM
parathyroid gland: 4.6 nTPM
tongue: 4.2 nTPM
salivary gland: 2.6 nTPM

Single-cell type

urothelial cells: 384 nCPM
prostatic club cells: 74 nCPM
prostatic glandular cells: 65 nCPM
enterocytes: 27 nCPM
prostatic hillock cells: 21 nCPM
papillary tip epithelial cells: 14 nCPM

Immune cell

myeloid DC: 87 nTPM
plasmacytoid DC: 33 nTPM
non-classical monocyte: 32 nTPM
intermediate monocyte: 26 nTPM
classical monocyte: 21 nTPM
total PBMC: 7.5 nTPM

Brain region

choroid plexus: 0.9 nTPM
white matter: 0.7 nTPM
hypothalamus: 0.6 nTPM
medulla oblongata: 0.6 nTPM
pons: 0.6 nTPM
cerebellum: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Uroplakin-3
Uroplakin-3a

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UPK3A as an antibody target. Whether an autoantibody or antibody against UPK3A could matter depends on whether native UPK3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UPK3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UPK3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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