UPK2
Uroplakin-2
Also known as: MGC138598, UP2, UPII, UPK2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O00526
- Gene
- UPK2
- Ensembl
- ENSG00000110375
- Chromosome
- 11
- Canonical length
- 184 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]
Canonical amino-acid sequenceUniProt
184 residues, UniProt reviewed canonical sequence.
>O00526|UPK2
1 MAPLLPIRTL PLILILLALL SPGAADFNIS SLSGLLSPAL TESLLVALPP CHLTGGNATL
61 MVRRANDSKV VTSSFVVPPC RGRRELVSVV DSGAGFTVTR LSAYQVTNLV PGTKFYISYL
121 VKKGTATESS REIPMSTLPR RNMESIGLGM ARTGGMVVIT VLLSVAMFLL VLGFIIALAL
181 GSRKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UPK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 62 nTPM
Expression across tissuesHPA
Tissue
- urinary bladder: 62 nTPM
- esophagus: 2.4 nTPM
- vagina: 2.2 nTPM
- adipose tissue: 1.3 nTPM
- basal ganglia: 0.6 nTPM
- kidney: 0.5 nTPM
Single-cell type
- urothelial cells: 139 nCPM
- prostatic club cells: 33 nCPM
- migrating cytotrophoblasts: 30 nCPM
- esophageal apical cells: 24 nCPM
- prostatic hillock cells: 21 nCPM
- papillary tip epithelial cells: 14 nCPM
Immune cell
- NK-cell: 0.4 nTPM
- T-reg: 0.3 nTPM
- memory B-cell: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- hypothalamus: 0.4 nTPM
- white matter: 0.4 nTPM
- amygdala: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- basal ganglia: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.9
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Uroplakin-2
- Uroplakin II
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UPK2 as an antibody target. Whether an autoantibody or antibody against UPK2 could matter depends on whether native UPK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UPK2 is annotated at the cell surface, where native UPK2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label UPK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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