Seroatlas · Human Serome Atlas

UNK

RING finger protein unkempt homolog

Also known as: KIAA1753, UNK_HUMAN, ZC3H5, ZC3HDC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C0B0
Gene: UNK
Ensembl: ENSG00000132478
Chromosome: 17
Canonical length: 810 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol,Cytoplasmic bodies

OverviewNCBI Gene

Enables mRNA CDS binding activity. Involved in cell morphogenesis involved in neuron differentiation and negative regulation of cytoplasmic translation. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

810 residues, UniProt reviewed canonical sequence.

>Q9C0B0|UNK
     1  MSKGPGPGGS AASSAPPAAT AQVLQAQPEK PQHYTYLKEF RTEQCPLFVQ HKCTQHRPYT
    61  CFHWHFVNQR RRRSIRRRDG TFNYSPDVYC TKYDEATGLC PEGDECPFLH RTTGDTERRY
   121  HLRYYKTGIC IHETDSKGNC TKNGLHCAFA HGPHDLRSPV YDIRELQAME ALQNGQTTVE
   181  GSIEGQSAGA ASHAMIEKIL SEEPRWQETA YVLGNYKTEP CKKPPRLCRQ GYACPYYHNS
   241  KDRRRSPRKH KYRSSPCPNV KHGDEWGDPG KCENGDACQY CHTRTEQQFH PEIYKSTKCN
   301  DMQQSGSCPR GPFCAFAHVE QPPLSDDLQP SSAVSSPTQP GPVLYMPSAA GDSVPVSPSS
   361  PHAPDLSALL CRNSSLGSPS NLCGSPPGSI RKPPNLEGIV FPGESGLAPG SYKKAPGFER
   421  EDQVGAEYLK NFKCQAKLKP HSLEPRSQEQ PLLQPKQDML GILPAGSPLT SSISSSITSS
   481  LAATPPSPVG TSSVPGMNAN ALPFYPTSDT VESVIESALD DLDLNEFGVA ALEKTFDNST
   541  VPHPGSITIG GSLLQSSAPV NIPGSLGSSA SFHSASPSPP VSLSSHFLQQ PQGHLSQSEN
   601  TFLGTSASHG SLGLNGMNSS IWEHFASGSF SPGTSPAFLS GPGAAELARL RQELDEANST
   661  IKQWEESWKQ AKQACDAWKK EAEEAGERAS AAGAECELAR EQRDALEVQV KKLQEELERL
   721  HAGPEPQALP AFSDLEALSL STLYSLQKQL RAHLEQVDKA VFHMQSVKCL KCQEQKRAVL
   781  PCQHAALCEL CAEGSECPIC QPGRAHTLQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

ovary: 22 nTPM
spleen: 20 nTPM
cervix: 20 nTPM
pituitary gland: 20 nTPM
endometrium: 18 nTPM
skin: 18 nTPM

Single-cell type

early spermatids: 204 nCPM
early primary spermatocytes: 152 nCPM
somatotrophs: 147 nCPM
choroid plexus epithelial cells: 129 nCPM
lactotrophs: 123 nCPM
thyrotrophs: 122 nCPM

Immune cell

naive B-cell: 0.7 nTPM
gdT-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
plasmacytoid DC: 0.4 nTPM

Brain region

white matter: 29 nTPM
cerebral cortex: 23 nTPM
thalamus: 23 nTPM
choroid plexus: 22 nTPM
medulla oblongata: 22 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.72
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNK as an antibody target. Whether an autoantibody or antibody against UNK could matter depends on whether native UNK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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