UNC79

Protein identityUniProt · HPA

UniProt accession

Q9P2D8

Gene

UNC79

Ensembl

ENSG00000133958

Chromosome

14

Canonical length

2635 aa

Protein class

Predicted membrane proteins, Transporters

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

The NALCN channel is responsible for Na(+) leak currents. The protein encoded by this gene, along with UNC80, is an accessory subunit of the NALCN channel that contributes to the Ca(2+) sensitivity of the channel. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

2635 residues, UniProt reviewed canonical sequence.

>Q9P2D8|UNC79
     1  MSTKAEQFAS KIRYLQEYHN RVLHNIYPVP SGTDIANTLK YFSQTLLSIL SRTGKKENQD
    61  ASNLTVPMTM CLFPVPFPLT PSLRPQVSSI NPTVTRSLLY SVLRDAPSER GPQSRDAQLS
   121  DYPSLDYQGL YVTLVTLLDL VPLLQHGQHD LGQSIFYTTT CLLPFLNDDI LSTLPYTMIS
   181  TLATFPPFLH KDIIEYLSTS FLPMAILGSS RREGVPAHVN LSASSMLMIA MQYTSNPVYH
   241  CQLLECLMKY KQEVWKDLLY VIAYGPSQVK PPAVQMLFHY WPNLKPPGAI SEYRGLQYTA
   301  WNPIHCQHIE CHNAINKPAV KMCIDPSLSV ALGDKPPPLY LCEECSERIA GDHSEWLIDV
   361  LLPQAEISAI CQKKNCSSHV RRAVVTCFSA GCCGRHGNRP VRYCKRCHSN HHSNEVGAAA
   421  ETHLYQTSPP PINTRECGAE ELVCAVEAVI SLLKEAEFHA EQREHELNRR RQLGLSSSHH
   481  SLDNADFDNK DDDKHDQRLL SQFGIWFLVS LCTPSENTPT ESLARLVAMV FQWFHSTAYM
   541  MDDEVGSLVE KLKPQFVTKW LKTVCDVRFD VMVMCLLPKP MEFARVGGYW DKSCSTVTQL
   601  KEGLNRILCL IPYNVINQSV WECIMPEWLE AIRTEVPDNQ LKEFREVLSK MFDIELCPLP
   661  FSMEEMFGFI SCRFTGYPSS VQEQALLWLH VLSELDIMVP LQLLISMFSD GVNSVKELAN
   721  QRKSRVSELA GNLASRRVSV ASDPGRRVQH NMLSPFHSPF QSPFRSPLRS PFRSPFKNFG
   781  HPGGRTIDFD CEDDEMNLNC FILMFDLLLK QMELQDDGIT MGLEHSLSKD IISIINNVFQ
   841  APWGGSHTCQ KDEKAIECNL CQSSILCYQL ACELLERLAP KEESRLVEPT DSLEDSLLSS
   901  RPEFIIGPEG EEEENPASKH GENPGNCTEP VEHAAVKNDT ERKFCYQQLP VTLRLIYTIF
   961  QEMAKFEEPD ILFNMLNCLK ILCLHGECLY IARKDHPQFL AYIQDHMLIA SLWRVVKSEF
  1021  SQLSSLAVPL LLHALSLPHG ADIFWTIING NFNSKDWKMR FEAVEKVAVI CRFLDIHSVT
  1081  KNHLLKYSLA HAFCCFLTAV EDVNPAVATR AGLLLDTIKR PALQGLCLCL DFQFDTVVKD
  1141  RPTILSKLLL LHFLKQDIPA LSWEFFVNRF ETLSLEAQLH LDCNKEFPFP TTITAVRTNV
  1201  ANLSDAALWK IKRARFARNR QKSVRSLRDS VKGPVESKRA LSLPETLTSK IRQQSPENDN
  1261  TIKDLLPEDA GIDHQTVHQL ITVLMKFMAK DESSAESDIS SAKAFNTVKR HLYVLLGYDQ
  1321  QEGCFMIAPQ KMRLSTCFNA FIAGIAQVMD YNINLGKHLL PLVVQVLKYC SCPQLRHYFQ
  1381  QPPRCSLWSL KPHIRQMWLK ALLVILYKYP YRDCDISKIL LHLIHITVNT LNAQYHSCKP
  1441  HATAGPLYSD NSNISRYSEK EKGEIELAEY RETGALQDSL LHCVREESIP KKKLRSFKQK
  1501  SLDIGNADSL LFTLDEHRRK SCIDRCDIEK PPTQAAYIAQ RPNDPGRSRQ NSATRPDNSE
  1561  IPENPAMEGF PDARRPVIPE VRLNCMETFE VKVDSPVKPA PKEDLDLIDL SSDSTSGPEK
  1621  HSILSTSDSD SLVFEPLPPL RIVESDEEEE TMNQGDDGPS GKNAASSPSV PSHPSVLSLS
  1681  TAPLVQVSVE DCSKDFSSKD SGNNQSAGNT DSALITLEDP MDAEGSSKPE ELPEFSCGSP
  1741  LTLKQKRDLL QKSFALPEMS LDDHPDPGTE GEKPGELMPS SGAKTVLLKV PEDAENPTES
  1801  EKPDTSAESD TEQNPERKVE EDGAEESEFK IQIVPRQRKQ RKIAVSAIQR EYLDISFNIL
  1861  DKLGEQKDPD PSTKGLSTLE MPRESSSAPT LDAGVPETSS HSSISTQYRQ MKRGSLGVLT
  1921  MSQLMKRQLE HQSSAPHNIS NWDTEQIQPG KRQCNVPTCL NPDLEGQPLR MRGATKSSLL
  1981  SAPSIVSMFV PAPEEFTDEQ PTVMTDKCHD CGAILEEYDE ETLGLAIVVL STFIHLSPDL
  2041  AAPLLLDIMQ SVGRLASSTT FSNQAESMMV PGNAAGVAKQ FLRCIFHQLA PNGIFPQLFQ
  2101  STIKDGTFLR TLASSLMDFN ELSSIAALSQ LLEGLNNKKN LPAGGAMIRC LENIATFMEA
  2161  LPMDSPSSLW TTISNQFQTF FAKLPCVLPL KCSLDSSLRI MICLLKIPST NATRSLLEPF
  2221  SKLLSFVIQN AVFTLAYLVE LCGLCYRAFT KERDKFYLSR SVVLELLQAL KLKSPLPDTN
  2281  LLLLVQFICA DAGTKLAEST ILSKQMIASV PGCGTAAMEC VRQYINEVLD FMADMHTLTK
  2341  LKSHMKTCSQ PLHEDTFGGH LKVGLAQIAA MDISRGNHRD NKAVIRYLPW LYHPPSAMQQ
  2401  GPKEFIECVS HIRLLSWLLL GSLTHNAVCP NASSPCLPIP LDAGSHVADH LIVILIGFPE
  2461  QSKTSVLHMC SLFHAFIFAQ LWTVYCEQSA VATNLQNQNE FSFTAILTAL EFWSRVTPSI
  2521  LQLMAHNKVM VEMVCLHVIS LMEALQECNS TIFVKLIPMW LPMIQSNIKH LSAGLQLRLQ
  2581  AIQNHVNHHS LRTLPGSGQS SAGLAALRKW LQCTQFKMAQ VEIQSSEAAS QFYPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC79 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

2

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UNC79.

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 419 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Inborn genetic diseases
• Neurodevelopmental disorder
• UNC79-related disorder
• UNC79-related neurodevelopmental disorder
• UNC79-associated seizure disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.15

gnomAD pLI

1

gnomAD missense Z

4.16

DepMap mean gene effect

0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Armadillo-type fold
• UNC79
• Protein unc-79 homolog, N-terminal region

KeywordsUniProt

• Cell membrane
• Membrane
• Phosphoprotein
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of UNC79 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UNC80