Seroatlas · Human Serome Atlas

UNC50

Protein unc-50 homolog

Also known as: GMH1, UNC50_HUMAN, UNCL, URP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53HI1
Gene: UNC50
Ensembl: ENSG00000115446
Chromosome: 2
Canonical length: 259 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in nuclear inner membrane. Predicted to be active in Golgi membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q53HI1|UNC50
     1  MLPSTSVNSL VQGNGVLNSR DAARHTAGAK RYKYLRRLFR FRQMDFEFAA WQMLYLFTSP
    61  QRVYRNFHYR KQTKDQWARD DPAFLVLLSI WLCVSTIGFG FVLDMGFFET IKLLLWVVLI
   121  DCVGVGLLIA TLMWFISNKY LVKRQSRDYD VEWGYAFDVH LNAFYPLLVI LHFIQLFFIN
   181  HVILTDTFIG YLVGNTLWLV AVGYYIYVTF LGYSALPFLK NTVILLYPFA PLILLYGLSL
   241  ALGWNFTHTL CSFYKYRVK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UNC50 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 5
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 77 nTPM
epididymis: 65 nTPM
thyroid gland: 60 nTPM
retina: 56 nTPM
salivary gland: 53 nTPM
choroid plexus: 52 nTPM

Single-cell type

late primary spermatocytes: 199 nCPM
syncytiotrophoblasts: 196 nCPM
early primary spermatocytes: 157 nCPM
cytotrophoblasts: 144 nCPM
parietal cells: 120 nCPM
migrating cytotrophoblasts: 109 nCPM

Immune cell

eosinophil: 67 nTPM
basophil: 62 nTPM
NK-cell: 59 nTPM
intermediate monocyte: 55 nTPM
myeloid DC: 55 nTPM
classical monocyte: 54 nTPM

Brain region

choroid plexus: 46 nTPM
white matter: 46 nTPM
spinal cord: 36 nTPM
medulla oblongata: 36 nTPM
cerebellum: 35 nTPM
hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.01
gnomAD pLI: 0
gnomAD missense Z: 0.94
DepMap mean gene effect: -0.45
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein localization to cell surface

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

UNC-50
UNC-50 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UNC50 as an antibody target. Whether an autoantibody or antibody against UNC50 could matter depends on whether native UNC50 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UNC50 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UNC50 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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