Seroatlas · Human Serome Atlas

UMAD1

UBAP1-MVB12-associated (UMA)-domain containing protein 1

Also known as: RPA3-AS1, RPA3OS, UMAD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C9J7I0
Gene
UMAD1
Ensembl
ENSG00000219545
Chromosome
7
Canonical length
137 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

No narrative summary is available for UMAD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>C9J7I0|UMAD1
     1  MFHFFRKPPE SKKPSVPETE ADGFVLLGDT TDEQRMTARG KTSDIEANQP LETNKENSSS
    61  VTVSDPEMEN KAGQTLENSS LMAELLSDVP FTLAPHVLAV QGTITDLPDH LLSYDGSENL
   121  SRFWYDFTLE NSVLCDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UMAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 31 nTPM
  • parathyroid gland: 29 nTPM
  • thyroid gland: 24 nTPM
  • stomach: 22 nTPM
  • salivary gland: 19 nTPM
  • prostate: 19 nTPM

Single-cell type

  • renal collecting duct intercalated cells: 373 nCPM
  • distal convoluted tubule cells: 280 nCPM
  • podocytes: 278 nCPM
  • renal connecting tubule cells: 270 nCPM
  • renal collecting duct principal cells: 223 nCPM
  • loop of henle epithelial cells: 221 nCPM

Immune cell

  • neutrophil: 43 nTPM
  • basophil: 41 nTPM
  • eosinophil: 40 nTPM
  • T-reg: 33 nTPM
  • naive CD4 T-cell: 29 nTPM
  • memory B-cell: 27 nTPM

Brain region

  • hypothalamus: 22 nTPM
  • choroid plexus: 20 nTPM
  • midbrain: 20 nTPM
  • pons: 20 nTPM
  • white matter: 19 nTPM
  • medulla oblongata: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0.23

Protein domainsUniProt · Pfam · InterPro

  • UMA domain
  • UBAP1-MVB12-associated (UMA)-domain containing protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UMAD1 as an antibody target. Whether an autoantibody or antibody against UMAD1 could matter depends on whether native UMAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UMAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UMAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UMAD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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