Seroatlas · Human Serome Atlas

ULK4

Serine/threonine-protein kinase ULK4

Also known as: FAM7C1, FLJ20574, REC01035, ULK4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96C45
Gene
ULK4
Ensembl
ENSG00000168038
Chromosome
3
Canonical length
1275 aa
Protein class
Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Primary cilium transition zone,Cytosol

OverviewNCBI Gene

This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

1275 residues, UniProt reviewed canonical sequence.

>Q96C45|ULK4
     1  MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT REIKHKNIVT
    61  FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE FGIDLISGLH HLHKLGILFC
   121  DISPRKILLE GPGTLKFSNF CLAKVEGENL EEFFALVAAE EGGGDNGENV LKKSMKSRVK
   181  GSPVYTAPEV VRGADFSISS DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI
   241  PKDSSRPKAS SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR
   301  NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL EGQLNESMFL
   361  LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL SQQDLESQMR ELIYTDSDLV
   421  VTPIIDNPKI MKQPPVKFDA KILHLPTYSV DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG
   481  ASRAKLNLLC YLCVVAGHQE VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH
   541  TAELQENTPV VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA
   601  VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP ILWYLFRHST
   661  ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA SAICKVQQYM LTLFAAMLSC
   721  GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA KAFLVLLYIL IYNREMLLLS CQARLVMYIE
   781  RDSRKTTPGK EQQSGNEYLS KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK
   841  QLKLCLPLMP VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS
   901  EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF SLRLLSETTS
   961  LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE PDPVPAYALK LLVAMTEHNP
  1021  TFTRLVEESK LIPLIFEVTL EHQESILGNT MQSVIALLSN LVACKDSNME LLYEQGLVSH
  1081  ICNLLTETAT LCLDVDNKNN NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED
  1141  PQAAEDLLLL NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV
  1201  EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL APGSGSFADS
  1261  AVAPLALEIL QAVGH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ULK4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • testis: 22 nTPM
  • heart muscle: 8.9 nTPM
  • fallopian tube: 8.5 nTPM
  • bone marrow: 8 nTPM
  • parathyroid gland: 7.5 nTPM
  • choroid plexus: 6.8 nTPM

Single-cell type

  • decidual stromal cells: 2,243 nCPM
  • ependymal cells: 1,531 nCPM
  • respiratory ciliated cells: 1,486 nCPM
  • endometrial ciliated cells: 1,031 nCPM
  • fallopian tube ciliated cells: 727 nCPM
  • late spermatids: 699 nCPM

Immune cell

  • T-reg: 7.8 nTPM
  • neutrophil: 6.6 nTPM
  • naive CD8 T-cell: 5.8 nTPM
  • memory CD4 T-cell: 5.3 nTPM
  • gdT-cell: 5.1 nTPM
  • naive B-cell: 4.7 nTPM

Brain region

  • choroid plexus: 43 nTPM
  • midbrain: 24 nTPM
  • medulla oblongata: 23 nTPM
  • spinal cord: 19 nTPM
  • pons: 14 nTPM
  • hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ULK4.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 272 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
-0.91
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ULK4 as an antibody target. Whether an autoantibody or antibody against ULK4 could matter depends on whether native ULK4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ULK4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ULK4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ULK4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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