Seroatlas · Human Serome Atlas

UGGT1

UDP-glucose:glycoprotein glucosyltransferase 1

Also known as: HUGT1, UGCGL1, UGGG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYU2
Gene: UGGT1
Ensembl: ENSG00000136731
Chromosome: 2
Canonical length: 1555 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Primary cilium,Cytosol
Secretome location: Intracellular and membrane

OverviewNCBI Gene

UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]

Canonical amino-acid sequenceUniProt

1555 residues, UniProt reviewed canonical sequence.

>Q9NYU2|UGGT1
     1  MGCKGDASGA CAAGALPVTG VCYKMGVLVV LTVLWLFSSV KADSKAITTS LTTKWFSTPL
    61  LLEASEFLAE DSQEKFWNFV EASQNIGSSD HDGTDYSYYH AILEAAFQFL SPLQQNLFKF
   121  CLSLRSYSAT IQAFQQIAAD EPPPEGCNSF FSVHGKKTCE SDTLEALLLT ASERPKPLLF
   181  KGDHRYPSSN PESPVVIFYS EIGSEEFSNF HRQLISKSNA GKINYVFRHY IFNPRKEPVY
   241  LSGYGVELAI KSTEYKAKDD TQVKGTEVNT TVIGENDPID EVQGFLFGKL RDLHPDLEGQ
   301  LKELRKHLVE STNEMAPLKV WQLQDLSFQT AARILASPVE LALVVMKDLS QNFPTKARAI
   361  TKTAVSSELR TEVEENQKYF KGTLGLQPGD SALFINGLHM DLDTQDIFSL FDVLRNEARV
   421  MEGLHRLGIE GLSLHNVLKL NIQPSEADYA VDIRSPAISW VNNLEVDSRY NSWPSSLQEL
   481  LRPTFPGVIR QIRKNLHNMV FIVDPAHETT AELMNTAEMF LSNHIPLRIG FIFVVNDSED
   541  VDGMQDAGVA VLRAYNYVAQ EVDDYHAFQT LTHIYNKVRT GEKVKVEHVV SVLEKKYPYV
   601  EVNSILGIDS AYDRNRKEAR GYYEQTGVGP LPVVLFNGMP FEREQLDPDE LETITMHKIL
   661  ETTTFFQRAV YLGELPHDQD VVEYIMNQPN VVPRINSRIL TAERDYLDLT ASNNFFVDDY
   721  ARFTILDSQG KTAAVANSMN YLTKKGMSSK EIYDDSFIRP VTFWIVGDFD SPSGRQLLYD
   781  AIKHQKSSNN VRISMINNPA KEISYENTQI SRAIWAALQT QTSNAAKNFI TKMAKEGAAE
   841  ALAAGADIAE FSVGGMDFSL FKEVFESSKM DFILSHAVYC RDVLKLKKGQ RAVISNGRII
   901  GPLEDSELFN QDDFHLLENI ILKTSGQKIK SHIQQLRVEE DVASDLVMKV DALLSAQPKG
   961  DPRIEYQFFE DRHSAIKLRP KEGETYFDVV AVVDPVTREA QRLAPLLLVL AQLINMNLRV
  1021  FMNCQSKLSD MPLKSFYRYV LEPEISFTSD NSFAKGPIAK FLDMPQSPLF TLNLNTPESW
  1081  MVESVRTPYD LDNIYLEEVD SVVAAEYELE YLLLEGHCYD ITTGQPPRGL QFTLGTSANP
  1141  VIVDTIVMAN LGYFQLKANP GAWILRLRKG RSEDIYRIYS HDGTDSPPDA DEVVIVLNNF
  1201  KSKIIKVKVQ KKADMVNEDL LSDGTSENES GFWDSFKWGF TGQKTEEVKQ DKDDIINIFS
  1261  VASGHLYERF LRIMMLSVLK NTKTPVKFWF LKNYLSPTFK EFIPYMANEY NFQYELVQYK
  1321  WPRWLHQQTE KQRIIWGYKI LFLDVLFPLV VDKFLFVDAD QIVRTDLKEL RDFNLDGAPY
  1381  GYTPFCDSRR EMDGYRFWKS GYWASHLAGR KYHISALYVV DLKKFRKIAA GDRLRGQYQG
  1441  LSQDPNSLSN LDQDLPNNMI HQVPIKSLPQ EWLWCETWCD DASKKRAKTI DLCNNPMTKE
  1501  PKLEAAVRIV PEWQDYDQEI KQLQIRFQKE KETGALYKEK TKEPSREGPQ KREEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UGGT1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 20 nTPM
epididymis: 19 nTPM
pancreas: 14 nTPM
liver: 14 nTPM
appendix: 13 nTPM
skeletal muscle: 12 nTPM

Single-cell type

erythrocyte progenitors: 223 nCPM
megakaryocyte-erythroid progenitors: 131 nCPM
neutrophil progenitors: 126 nCPM
neutrophils: 116 nCPM
gonadotrophs: 108 nCPM
monocyte progenitors: 107 nCPM

Immune cell

basophil: 3.7 nTPM
neutrophil: 3.6 nTPM
naive B-cell: 3.3 nTPM
plasmacytoid DC: 3.1 nTPM
classical monocyte: 2.5 nTPM
intermediate monocyte: 2.5 nTPM

Brain region

cerebral cortex: 22 nTPM
white matter: 19 nTPM
choroid plexus: 18 nTPM
medulla oblongata: 18 nTPM
hypothalamus: 18 nTPM
thalamus: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UGGT1.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 263 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Congenital disorder of glycosylation, type IIcc
Hypercholesterolemia, familial, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 1.08
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UGGT1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

METTL23

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UGGT1 as an antibody target. Whether an autoantibody or antibody against UGGT1 could matter depends on whether native UGGT1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UGGT1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UGGT1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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