Seroatlas · Human Serome Atlas

UFSP1

Ufm1-specific protease 1

Also known as: UFSP, UFSP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6NVU6
Gene: UFSP1
Ensembl: ENSG00000176125
Chromosome: 7
Canonical length: 218 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]

Canonical amino-acid sequenceUniProt

218 residues, UniProt reviewed canonical sequence.

>Q6NVU6|UFSP1
     1  MEPLRDVHVG LSPPSRGPVR LALLSGHYLY YHYGCDGLDD RGWGCGYRTL QTLCSWPEGQ
    61  PAGVPGLAAV QAALEDMGDK PPGFRGSRDW IGCVEASLCL AHFGGPQGRL CHVPRGVGLH
   121  GELERLYSHF AGGGGPVMVG GDADARSKAL LGVCVGSGTE AYVLVLDPHY WGTPKSPSEL
   181  QAAGWVGWQE VSAAFDPNSF YNLCLTSLSS QQQQRTLD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UFSP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 3.6 nTPM
liver: 3 nTPM
pancreas: 3 nTPM
adrenal gland: 2.5 nTPM
endometrium: 2.2 nTPM
pituitary gland: 2.2 nTPM

Single-cell type

epididymal principal cells: 12 nCPM
adrenal medulla cells: 11 nCPM
hepatic stellate cells: 6.5 nCPM
epididymal clear cells: 6.1 nCPM
decidual stromal cells: 5.3 nCPM
gastric progenitor cells: 5.1 nCPM

Immune cell

plasmacytoid DC: 4.4 nTPM
naive B-cell: 4 nTPM
naive CD8 T-cell: 3.6 nTPM
MAIT T-cell: 3.5 nTPM
gdT-cell: 3.1 nTPM
NK-cell: 3 nTPM

Brain region

cerebral cortex: 5.6 nTPM
cerebellum: 5.3 nTPM
midbrain: 4.6 nTPM
white matter: 4.5 nTPM
medulla oblongata: 4.3 nTPM
pons: 4.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.03
gnomAD missense Z: -1.58
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UFSP1 as an antibody target. Whether an autoantibody or antibody against UFSP1 could matter depends on whether native UFSP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UFSP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UFSP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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