Seroatlas · Human Serome Atlas

UCP2

Dicarboxylate carrier SLC25A8

Also known as: BMIQ4, SLC25A8, UCP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55851
Gene
UCP2
Ensembl
ENSG00000175567
Chromosome
11
Canonical length
309 aa
Protein class
Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria
Quaternary structure
Homotetramer

OverviewNCBI Gene

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P55851|UCP2
     1  MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGP VRATASAQYR
    61  GVMGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHASIGSRL
   121  LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV NAYKTIAREE GFRGLWKGTS
   181  PNVARNAIVN CAELVTYDLI KDALLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT
   241  RYMNSALGQY SSAGHCALTM LQKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA
   301  ACTSREAPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
260 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 260 nTPM
  • spleen: 235 nTPM
  • tonsil: 225 nTPM
  • thymus: 203 nTPM
  • fallopian tube: 165 nTPM
  • appendix: 135 nTPM

Single-cell type

  • hofbauer cells: 659 nCPM
  • kupffer cells: 370 nCPM
  • pdcs: 346 nCPM
  • platelets: 332 nCPM
  • fallopian tube ciliated cells: 231 nCPM
  • respiratory ciliated cells: 203 nCPM

Immune cell

  • plasmacytoid DC: 3,014 nTPM
  • total PBMC: 2,964 nTPM
  • T-reg: 2,597 nTPM
  • intermediate monocyte: 1,946 nTPM
  • memory B-cell: 1,922 nTPM
  • naive B-cell: 1,860 nTPM

Brain region

  • white matter: 42 nTPM
  • thalamus: 34 nTPM
  • choroid plexus: 33 nTPM
  • pons: 29 nTPM
  • medulla oblongata: 28 nTPM
  • spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
0
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCP2 as an antibody target. Whether an autoantibody or antibody against UCP2 could matter depends on whether native UCP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UCP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UCP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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