UCP1

Protein identityUniProt · HPA

UniProt accession

P25874

Gene

UCP1

Ensembl

ENSG00000109424

Chromosome

4

Canonical length

307 aa

Protein class

Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters

Quaternary structure

Homotetramer

OverviewNCBI Gene

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>P25874|UCP1
     1  MGGLTASDVH PTLGVQLFSA GIAACLADVI TFPLDTAKVR LQVQGECPTS SVIRYKGVLG
    61  TITAVVKTEG RMKLYSGLPA GLQRQISSAS LRIGLYDTVQ EFLTAGKETA PSLGSKILAG
   121  LTTGGVAVFI GQPTEVVKVR LQAQSHLHGI KPRYTGTYNA YRIIATTEGL TGLWKGTTPN
   181  LMRSVIINCT ELVTYDLMKE AFVKNNILAD DVPCHLVSAL IAGFCATAMS SPVDVVKTRF
   241  INSPPGQYKS VPNCAMKVFT NEGPTAFFKG LVPSFLRLGS WNVIMFVCFE QLKRELSKSR
   301  QTMDCAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

6

Mean surface accessibility (rSASA)

0.33

Highest tissue expression

2.6 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.79

gnomAD pLI

0

gnomAD missense Z

0.22

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive thermogenesis
• brown fat cell differentiation
• cellular response to cold
• cellular response to fatty acid
• cellular response to hormone stimulus
• cellular response to reactive oxygen species
• diet induced thermogenesis
• mitochondrial transmembrane transport
• positive regulation of cold-induced thermogenesis
• proton transmembrane transport
• regulation of reactive oxygen species biosynthetic process
• regulation of transcription by RNA polymerase II
• response to cold
• response to nutrient levels
• response to temperature stimulus
• cellular response to dehydroepiandrosterone

Molecular functions

• cardiolipin binding
• GDP binding
• GTP binding
• long-chain fatty acid binding
• oxidative phosphorylation uncoupler activity
• proton transmembrane transporter activity
• transmembrane transporter activity
• purine ribonucleotide binding

Cellular components

• mitochondrial inner membrane
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Mitochondrial carrier protein
• Mitochondrial carrier protein, transmembrane region
• Mitochondrial carrier protein domain superfamily
• Mitochondrial Metabolite Transporter
• Mitochondrial carrier protein

KeywordsUniProt

• Diabetes mellitus
• Ion channel
• Ion transport
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Obesity
• Oxidation
• Repeat
• Transmembrane
• Transmembrane helix
• Transport