Seroatlas · Human Serome Atlas

UCN3

Urocortin-3

Also known as: SPC, UCN3_HUMAN, UCNIII

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969E3
Gene
UCN3
Ensembl
ENSG00000178473
Chromosome
10
Canonical length
161 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>Q969E3|UCN3
     1  MLMPVHFLLL LLLLLGGPRT GLPHKFYKAK PIFSCLNTAL SEAEKGQWED ASLLSKRSFH
    61  YLRSRDASSG EEEEGKEKKT FPISGARGGA RGTRYRYVSQ AQPRGKPRQD TAKSPHRTKF
   121  TLSLDVPTNI MNLLFNIAKA KNLRAQAAAN AHLMAQIGRK K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
8.2 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 8.2 nTPM
  • small intestine: 6.1 nTPM
  • pancreas: 5.4 nTPM
  • stomach: 3.2 nTPM
  • pituitary gland: 2.6 nTPM
  • rectum: 2.2 nTPM

Single-cell type

  • neuroendocrine cells: 212 nCPM
  • pancreatic islet cells: 42 nCPM
  • epicardial cells: 9.1 nCPM
  • respiratory ciliated cells: 4.9 nCPM
  • pituitary stem cells: 2.3 nCPM
  • respiratory secretory cells: 1.9 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 4.1 nTPM
  • basal ganglia: 2.5 nTPM
  • hypothalamus: 1.7 nTPM
  • midbrain: 1.2 nTPM
  • spinal cord: 0.3 nTPM
  • cerebral cortex: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UCN3.

Disease | ImmuneIEDB

Conditions an epitope on UCN3 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0.04
gnomAD missense Z
-0.14
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCN3 as an antibody target. Whether an autoantibody or antibody against UCN3 could matter depends on whether native UCN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCN3 is annotated as secreted, so native UCN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UCN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UCN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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