Seroatlas · Human Serome Atlas

UCN2

Urocortin-2

Also known as: SRP, UCN-II, UCN2_HUMAN, UCNI, URP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RP3
Gene: UCN2
Ensembl: ENSG00000145040
Chromosome: 3
Canonical length: 112 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q96RP3|UCN2
     1  MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS
    61  HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.62
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

skin: 12 nTPM
cervix: 4.3 nTPM
vagina: 4.1 nTPM
esophagus: 3.2 nTPM
prostate: 3 nTPM
salivary gland: 1.5 nTPM

Single-cell type

schwann cells: 5.5 nCPM
basal keratinocytes: 3.2 nCPM
epididymal basal cells: 1.7 nCPM
thymic myoid cells: 1.4 nCPM
gastric progenitor cells: 1.3 nCPM
ocular epithelial cells: 1.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
hypothalamus: 0.8 nTPM
cerebellum: 0.7 nTPM
medulla oblongata: 0.6 nTPM
pons: 0.6 nTPM
midbrain: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0.04
gnomAD missense Z: 0.19
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCN2 as an antibody target. Whether an autoantibody or antibody against UCN2 could matter depends on whether native UCN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCN2 is annotated as secreted, so native UCN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UCN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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