Seroatlas · Human Serome Atlas

UCMA

Unique cartilage matrix-associated protein

Also known as: C10orf49, GRP, UCMA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVF2
Gene: UCMA
Ensembl: ENSG00000165623
Chromosome: 10
Canonical length: 138 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>Q8WVF2|UCMA
     1  MTWRQAVLLS CFSAVVLLSM LREGTSVSVG TMQMAGEEAS EDAKQKIFMQ ESDASNFLKR
    61  RGKRSPKSRD EVNVENRQKL RVDELRREYY EEQRNEFENF VEEQNDEQEE RSREAVEQWR
   121  QWHYDGLHPS YLYNRHHT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCMA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

amygdala: 2.6 nTPM
ovary: 0.8 nTPM
pituitary gland: 0.8 nTPM
heart muscle: 0.5 nTPM
cervix: 0.2 nTPM
blood vessel: 0.1 nTPM

Single-cell type

oocytes: 157 nCPM
pdcs: 1.3 nCPM
pituitary stem cells: 0.9 nCPM
syncytiotrophoblasts: 0.8 nCPM
hematopoietic stem cells: 0.5 nCPM
ovarian stromal cells: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 4.2 nTPM
amygdala: 2.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

BMP binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Unique cartilage matrix-associated protein
Unique cartilage matrix associated protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UCMA as an antibody target. Whether an autoantibody or antibody against UCMA could matter depends on whether native UCMA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UCMA is annotated as secreted, so native UCMA circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label UCMA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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