UCHL3

Protein identityUniProt · HPA

UniProt accession

P15374

Gene

UCHL3

Ensembl

ENSG00000118939

Chromosome

13

Canonical length

230 aa

Protein class

Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the deubiquitinating enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>P15374|UCHL3
     1  MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMDPE LLSMVPRPVC AVLLLFPITE
    61  KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK
   121  KFLEESVSMS PEERARYLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL
   181  YELDGRKPFP INHGETSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UCHL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

60 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

1.04

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• post-translational protein modification
• protein catabolic process
• protein deubiquitination
• protein ubiquitination
• ubiquitin-dependent protein catabolic process

Molecular functions

• cysteine-type deubiquitinase activity
• deNEDDylase activity
• peptidase activity
• ubiquitin binding

Cellular components

• cytoplasm
• cytosol
• Golgi apparatus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Peptidase C12, ubiquitin carboxyl-terminal hydrolase
• Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
• Papain-like cysteine peptidase superfamily
• Ubiquitin carboxyl-terminal hydrolase family 1, cysteine active-site
• Ubiquitin carboxyl-terminal hydrolase, family 1

KeywordsUniProt

• Cytoplasm
• Hydrolase
• Phosphoprotein
• Protease
• Thiol protease
• Ubl conjugation pathway

InteractionsUniProt · HPA

Protein binding partners of UCHL3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CLPB