UBTFL1
Upstream-binding factor 1-like protein 1
Also known as: C11orf27, UBFL1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P0CB47
- Gene
- UBTFL1
- Ensembl
- ENSG00000255009
- Chromosome
- 11
- Canonical length
- 393 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
OverviewNCBI Gene
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity and RNA polymerase I general transcription initiation factor activity. Predicted to be involved in positive regulation of transcription by RNA polymerase I and transcription by RNA polymerase I. Predicted to act upstream of or within blastocyst growth; embryo implantation; and regulation of gene expression. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
393 residues, UniProt reviewed canonical sequence.
>P0CB47|UBTFL1
1 MALPRSQGHW SNKDILRLLE CMENNRPSDD NSTFSSTQSH MDWGKVAFKN FSGEMCRLKW
61 LEISCNLRKF GTLKELVLEA KKCVKKMNKS QKYRNGPDFP KRPLTAYNRF FKESWPQYSQ
121 MYPGMRSQEL TKILSKKYRE LPEQMKQKYI QDFRKEKQEF EEKLARFREE HPDLVQKAKK
181 SSVSKRTQNK VQKKFQKNIE EVRSLPKTDR FFKKVKFHGE PQKPPMNGYH KFHQDSWSSK
241 EMQHLSVRER MVEIGRRWQR IPQSQKDHFK SQAEELQKQY KVKLDLWLKT LSPENYAAYK
301 ESTYAKGKNM AMTGGPDPRL KQADPQSSSA KGLQEGFGEG QGLQAAGTDS SQTIWVNCHV
361 SMEPEENRKK DREKEESSNS SDCSSGEEIE VDVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against UBTFL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- plasmacytoid DC: 0.4 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
OntologyGO
Biological processes
- blastocyst growth
- embryo implantation
- positive regulation of transcription by RNA polymerase I
- transcription by RNA polymerase I
Molecular functions
- RNA polymerase I core promoter sequence-specific DNA binding
- RNA polymerase I general transcription initiation factor activity
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads UBTFL1 as an antibody target. Whether an autoantibody or antibody against UBTFL1 could matter depends on whether native UBTFL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
UBTFL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label UBTFL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...