Seroatlas · Human Serome Atlas

UBR7

Putative E3 ubiquitin-protein ligase UBR7

Also known as: C14orf130, UBR7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N806
Gene
UBR7
Ensembl
ENSG00000012963
Chromosome
14
Canonical length
425 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a UBR box-containing protein that belongs to the E3 ubiquitin ligase family. The protein also contains a plant homeodomain (PHD) in the C-terminus. In mammals, the encoded protein recognizes N-degrons, the destabilizing N-terminal residues of short-lived proteins, which results in ubiquitinylation, and proteolysis via the proteasome. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

425 residues, UniProt reviewed canonical sequence.

>Q8N806|UBR7
     1  MAGAEGAAGR QSELEPVVSL VDVLEEDEEL ENEACAVLGG SDSEKCSYSQ GSVKRQALYA
    61  CSTCTPEGEE PAGICLACSY ECHGSHKLFE LYTKRNFRCD CGNSKFKNLE CKLLPDKAKV
   121  NSGNKYNDNF FGLYCICKRP YPDPEDEIPD EMIQCVVCED WFHGRHLGAI PPESGDFQEM
   181  VCQACMKRCS FLWAYAAQLA VTKISTEDDG LVRNIDGIGD QEVIKPENGE HQDSTLKEDV
   241  PEQGKDDVRE VKVEQNSEPC AGSSSESDLQ TVFKNESLNA ESKSGCKLQE LKAKQLIKKD
   301  TATYWPLNWR SKLCTCQDCM KMYGDLDVLF LTDEYDTVLA YENKGKIAQA TDRSDPLMDT
   361  LSSMNRVQQV ELICEYNDLK TELKDYLKRF ADEGTVVKRE DIQQFFEEFQ SKKRRRVDGM
   421  QYYCS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 32 nTPM
  • tonsil: 26 nTPM
  • parathyroid gland: 24 nTPM
  • tongue: 24 nTPM
  • retina: 23 nTPM
  • cerebral cortex: 22 nTPM

Single-cell type

  • late spermatids: 478 nCPM
  • early spermatids: 295 nCPM
  • late primary spermatocytes: 158 nCPM
  • megakaryocytes: 19 nCPM
  • erythrocyte progenitors: 13 nCPM
  • choroid plexus epithelial cells: 12 nCPM

Immune cell

  • basophil: 35 nTPM
  • T-reg: 27 nTPM
  • memory B-cell: 27 nTPM
  • naive B-cell: 21 nTPM
  • MAIT T-cell: 20 nTPM
  • non-classical monocyte: 18 nTPM

Brain region

  • basal ganglia: 23 nTPM
  • cerebral cortex: 23 nTPM
  • white matter: 22 nTPM
  • choroid plexus: 21 nTPM
  • thalamus: 20 nTPM
  • spinal cord: 19 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBR7.

Disease | AllUniProt

Conditions UBR7 is implicated in, by any mechanism.

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 66 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.45
gnomAD pLI
0.49
gnomAD missense Z
1.85
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBR7 as an antibody target. Whether an autoantibody or antibody against UBR7 could matter depends on whether native UBR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBR7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UBR7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...