Seroatlas · Human Serome Atlas

UBE3D

E3 ubiquitin-protein ligase E3D

Also known as: C6orf157, DKFZp434A1520, H10BH, UBE2CBP, UBE3D_HUMAN, YJR141W

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z6J8
Gene: UBE3D
Ensembl: ENSG00000118420
Chromosome: 6
Canonical length: 389 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Rods & Rings

OverviewNCBI Gene

Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. Is active in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

389 residues, UniProt reviewed canonical sequence.

>Q7Z6J8|UBE3D
     1  MAASAAETRV FLEVRGQLQS ALLILGEPKE GGMPMNISIM PSSLQMKTPE GCTEIQLPAE
    61  VRLVPSSCRG LQFVVGDGLH LRLQTQAKLG TKLISMFNQS SQTQECCTFY CQSCGEVIIK
   121  DRKLLRVLPL PSENWGALVG EWCCHPDPFA NKSLHPQEND CFIGDSFFLV NLRTSLWQQR
   181  PELSPVEMCC VSSDNHCKLE PKANTKVICK RCKVMLGETV SSETTKFYMT EIIIQSSERS
   241  FPIIPRSWFV QSVIAQCLVQ LSSARSTFRF TIQGQDDKVY ILLWLLNSDS LVIESLRNSK
   301  YIKKFPLLEN TFKADSSSAW SAVKVLYQPC IKSRNEKLVS LWESDISVHP LTLPSATCLE
   361  LLLILSKSNA NLPSSLRRVN SFQVAFLKM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 4.7 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 4.7 nTPM
retina: 3.2 nTPM
cerebral cortex: 2.7 nTPM
hypothalamus: 2.7 nTPM
skeletal muscle: 2.5 nTPM
thyroid gland: 2.5 nTPM

Single-cell type

ependymal cells: 603 nCPM
respiratory ciliated cells: 240 nCPM
adrenal medulla cells: 149 nCPM
oligodendrocyte progenitor cells: 144 nCPM
fallopian tube ciliated cells: 143 nCPM
somatotrophs: 138 nCPM

Immune cell

naive CD8 T-cell: 5.6 nTPM
memory B-cell: 4.7 nTPM
MAIT T-cell: 4.4 nTPM
T-reg: 4 nTPM
naive CD4 T-cell: 3.7 nTPM
memory CD4 T-cell: 3.5 nTPM

Brain region

cerebral cortex: 5.1 nTPM
midbrain: 4.8 nTPM
spinal cord: 4.3 nTPM
basal ganglia: 3.8 nTPM
hypothalamus: 3.8 nTPM
medulla oblongata: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Ubiquitin-conjugating enzyme E2-binding protein
HECT-like Ubiquitin-conjugating enzyme (E2)-binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE3D in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DNAAF2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE3D as an antibody target. Whether an autoantibody or antibody against UBE3D could matter depends on whether native UBE3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE3D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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