Seroatlas · Human Serome Atlas

UBE2T

Ubiquitin-conjugating enzyme E2 T

Also known as: FANCT, HSPC150, UBE2T_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPD8
Gene: UBE2T
Ensembl: ENSG00000077152
Chromosome: 1
Canonical length: 197 aa
Protein class: Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

The protein encoded by this gene catalyzes the covalent attachment of ubiquitin to protein substrates. Defects in this gene have been associated with Fanconi anemia of complementation group T. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q9NPD8|UBE2T
     1  MQRASRLKRE LHMLATEPPP GITCWQDKDQ MDDLRAQILG GANTPYEKGV FKLEVIIPER
    61  YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATVLTS IQLLMSEPNP
   121  DDPLMADISS EFKYNKPAFL KNARQWTEKH ARQKQKADEE EMLDNLPEAG DSRVHNSTQK
   181  RKASQLVGIE KKFHPDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2T can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

thymus: 45 nTPM
bone marrow: 28 nTPM
testis: 19 nTPM
lymph node: 18 nTPM
tonsil: 18 nTPM
skeletal muscle: 17 nTPM

Single-cell type

gastric progenitor cells: 210 nCPM
early primary spermatocytes: 137 nCPM
oocytes: 134 nCPM
late primary spermatocytes: 123 nCPM
migrating cytotrophoblasts: 115 nCPM
extravillous trophoblasts: 114 nCPM

Immune cell

T-reg: 11 nTPM
non-classical monocyte: 9.5 nTPM
memory B-cell: 9.4 nTPM
naive CD8 T-cell: 8.1 nTPM
naive B-cell: 6.8 nTPM
naive CD4 T-cell: 6.7 nTPM

Brain region

hypothalamus: 6.6 nTPM
pons: 5.4 nTPM
cerebral cortex: 5.2 nTPM
basal ganglia: 4.5 nTPM
thalamus: 4.5 nTPM
midbrain: 4.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UBE2T.

Disease | AllUniProt

Conditions UBE2T is implicated in, by any mechanism.

Fanconi anemia complementation group T (FANCT) MIM:616435

Disease | GeneticClinVar

12 pathogenic / likely-pathogenic of 78 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Fanconi anemia complementation group T

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.32
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2T in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2T as an antibody target. Whether an autoantibody or antibody against UBE2T could matter depends on whether native UBE2T is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2T is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2T as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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