Seroatlas · Human Serome Atlas

UBE2R2

Ubiquitin-conjugating enzyme E2 R2

Also known as: CDC34B, FLJ20419, MGC10481, UB2R2_HUMAN, UBC3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q712K3
Gene: UBE2R2
Ensembl: ENSG00000107341
Chromosome: 9
Canonical length: 238 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q712K3|UBE2R2
     1  MAQQQMTSSQ KALMLELKSL QEEPVEGFRI TLVDESDLYN WEVAIFGPPN TLYEGGYFKA
    61  HIKFPIDYPY SPPTFRFLTK MWHPNIYENG DVCISILHPP VDDPQSGELP SERWNPTQNV
   121  RTILLSVISL LNEPNTFSPA NVDASVMFRK WRDSKGKDKE YAEIIRKQVS ATKAEAEKDG
   181  VKVPTTLAEY CIKTKVPSND NSSDLLYDDL YDDDIDDEDE EEEDADCYDD DDSGNEES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 59 nTPM
pancreas: 48 nTPM
testis: 42 nTPM
tongue: 42 nTPM
blood vessel: 33 nTPM
skin: 32 nTPM

Single-cell type

neutrophils: 1,722 nCPM
monocytes: 528 nCPM
esophageal apical cells: 452 nCPM
myonuclei: 449 nCPM
early spermatids: 388 nCPM
late spermatids: 365 nCPM

Immune cell

neutrophil: 32 nTPM
basophil: 23 nTPM
non-classical monocyte: 19 nTPM
intermediate monocyte: 11 nTPM
classical monocyte: 11 nTPM
NK-cell: 7.4 nTPM

Brain region

white matter: 49 nTPM
medulla oblongata: 46 nTPM
pons: 45 nTPM
basal ganglia: 44 nTPM
cerebral cortex: 42 nTPM
midbrain: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 0.98
gnomAD missense Z: 2.78
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2R2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BTRC

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2R2 as an antibody target. Whether an autoantibody or antibody against UBE2R2 could matter depends on whether native UBE2R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2R2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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