Seroatlas · Human Serome Atlas

UBE2QL1

Ubiquitin-conjugating enzyme E2Q-like protein 1

Also known as: FLJ25076, U2QL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L167
Gene: UBE2QL1
Ensembl: ENSG00000215218
Chromosome: 5
Canonical length: 161 aa
Protein class: Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Enables ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

161 residues, UniProt reviewed canonical sequence.

>A1L167|UBE2QL1
     1  MKELQDIARL SDRFISVELV DESLFDWNVK LHQVDKDSVL WQDMKETNTE FILLNLTFPD
    61  NFPFSPPFMR VLSPRLENGY VLDGGAICME LLTPRGWSSA YTVEAVMRQF AASLVKGQGR
   121  ICRKAGKSKK SFSRKEAEAT FKSLVKTHEK YGWVTPPVSD G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2QL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 38 nTPM
cerebellum: 34 nTPM
cerebral cortex: 29 nTPM
retina: 26 nTPM
hippocampal formation: 19 nTPM
tongue: 13 nTPM

Single-cell type

rod photoreceptor cells: 193 nCPM
renal collecting duct intercalated cells: 135 nCPM
cone photoreceptor cells: 81 nCPM
pancreatic islet cells: 59 nCPM
myonuclei: 58 nCPM
brain excitatory neurons: 55 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 46 nTPM
white matter: 36 nTPM
hippocampal formation: 36 nTPM
cerebellum: 33 nTPM
basal ganglia: 28 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0.68
gnomAD missense Z: 2.14
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein polyubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2QL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FBXW7

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2QL1 as an antibody target. Whether an autoantibody or antibody against UBE2QL1 could matter depends on whether native UBE2QL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2QL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2QL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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