Seroatlas · Human Serome Atlas

UBE2Q1

Ubiquitin-conjugating enzyme E2 Q1

Also known as: NICE-5, PRO3094, UB2Q1_HUMAN, UBE2Q

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z7E8
Gene: UBE2Q1
Ensembl: ENSG00000160714
Chromosome: 1
Canonical length: 422 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Centrosome,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q7Z7E8|UBE2Q1
     1  MQQPQPQGQQ QPGPGQQLGG QGAAPGAGGG PGGGPGPGPC LRRELKLLES IFHRGHERFR
    61  IASACLDELS CEFLLAGAGG AGAGAAPGPH LPPRGSVPGD PVRIHCNITE SYPAVPPIWS
   121  VESDDPNLAA VLERLVDIKK GNTLLLQHLK RIISDLCKLY NLPQHPDVEM LDQPLPAEQC
   181  TQEDVSSEDE DEEMPEDTED LDHYEMKEEE PAEGKKSEDD GIGKENLAIL EKIKKNQRQD
   241  YLNGAVSGSV QATDRLMKEL RDIYRSQSFK GGNYAVELVN DSLYDWNVKL LKVDQDSALH
   301  NDLQILKEKE GADFILLNFS FKDNFPFDPP FVRVVSPVLS GGYVLGGGAI CMELLTKQGW
   361  SSAYSIESVI MQISATLVKG KARVQFGANK SQYSLTRAQQ SYKSLVQIHE KNGWYTPPKE
   421  DG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBE2Q1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 34 nTPM
testis: 33 nTPM
tonsil: 33 nTPM
spleen: 31 nTPM
bone marrow: 30 nTPM
pancreas: 30 nTPM

Single-cell type

megakaryocytes: 99 nCPM
platelets: 86 nCPM
kupffer cells: 83 nCPM
esophageal apical cells: 75 nCPM
neutrophils: 71 nCPM
breast myoepithelial cells: 54 nCPM

Immune cell

basophil: 3.9 nTPM
T-reg: 3.2 nTPM
eosinophil: 2.9 nTPM
memory CD8 T-cell: 2.7 nTPM
naive CD8 T-cell: 2.5 nTPM
plasmacytoid DC: 2.4 nTPM

Brain region

hypothalamus: 29 nTPM
cerebral cortex: 28 nTPM
pons: 28 nTPM
thalamus: 27 nTPM
basal ganglia: 26 nTPM
hippocampal formation: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.35
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 21% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBE2Q1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

STUB1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBE2Q1 as an antibody target. Whether an autoantibody or antibody against UBE2Q1 could matter depends on whether native UBE2Q1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBE2Q1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBE2Q1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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